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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Pediatr+Res 2016 ; 80 (1): 21-7 Nephropedia Template TP
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Clinical Associations of Immature Breathing in Preterm Infants Part 1: Central Apnea #MMPMID26959485
Fairchild K; Mohr M; Paget-Brown A; Tabacaru C; Lake D; Delos J; Moorman JR; Kattwinkel J
Pediatr Res 2016[Jul]; 80 (1): 21-7 PMID26959485show ga
Background: Apnea of prematurity (AOP) is nearly universal among very preterm infants, but neither the apnea burden nor its clinical associations have been systematically studied in a large consecutive cohort. Methods: We analyzed continuous bedside monitor chest impedance and electrocardiographic waveforms and oxygen saturation data collected on all NICU patients <35 weeks gestation from 2009?2014 (n=1211; >50 infant-years of data). ?ABDs?, defined as central apnea ?10 sec associated with both bradycardia <100 bpm and oxygen desaturation <80%, were identified using a validated automated algorithm. Results: Number and duration of apnea events decreased with increasing gestational age (GA) and post-menstrual age (PMA). ABDs were more frequent in infants <31 wks GA at birth but were not more frequent in those with severe ROP, BPD or severe IVH after accounting for GA. In the day before diagnosis of late-onset septicemia and necrotizing enterocolitis, ABD events were increased in some infants. Many infants continued to experience short ABD events in the week prior to discharge home. Conclusions: Frequency of apnea events is a function of GA and PMA in infants born preterm, and increased apnea is associated with acute but not with chronic pathologic conditions.