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10.1126/science.aad1210 http://scihub22266oqcxt.onion/10.1126/science.aad1210 C5015487!5015487!27313051     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2016 ; 352 (6292): aad1210 Nephropedia Template TP {{tp|p=27313051|t=2016. T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells |pdf=|usr=}}{{27313051}} gab.com Text T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=27313051 #FOAvip The NLRP3 inflammasome controls interleukin-1? maturation in antigen-presenting cells, but a direct role for NLRP3 in human adaptive immune cells has not been described. We found that the NLRP3 inflammasome assembles in human CD4+ T cells and initiates caspase-1?dependent interleukin-1? secretion, thereby promoting interferon-? production and T helper 1 (TH1) differentiation in an autocrine fashion. NLRP3 assembly requires intracellular C5 activation and stimulation of C5a receptor 1 (C5aR1), which is negatively regulated by surface-expressed C5aR2. Aberrant NLRP3 activity in T cells affects inflammatory responses in human autoinflammatory disease and in mouse models of inflammation and infection. Our results demonstrate that NLRP3 inflammasome activity is not confined to ?innate immune cells? but is an integral component of normal adaptive TH1 responses. Twit Text FOAVip T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells ????Science http://www.kidney.de/pget.php?&tw=1&pmid=27313051 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27313051 #FOAvip English Wikipedia <ref>{{Cite pmid|27313051}}</ref> T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells #MMPMID27313051 Arbore G; West EE; Spolski R; Robertson AAB; Klos A; Rheinheimer C; Dutow P; Woodruff TM; Yu ZX; O'Neill LA; Coll RC; Sher A; Leonard WJ; Köhl J; Monk P; Cooper MA; Arno M; Afzali B; Lachmann HJ; Cope AP; Mayer-Barber KD; Kemper C Science 2016[Jun]; 352 (6292): aad1210 PMID27313051show ga The NLRP3 inflammasome controls interleukin-1? maturation in antigen-presenting cells, but a direct role for NLRP3 in human adaptive immune cells has not been described. We found that the NLRP3 inflammasome assembles in human CD4+ T cells and initiates caspase-1?dependent interleukin-1? secretion, thereby promoting interferon-? production and T helper 1 (TH1) differentiation in an autocrine fashion. NLRP3 assembly requires intracellular C5 activation and stimulation of C5a receptor 1 (C5aR1), which is negatively regulated by surface-expressed C5aR2. Aberrant NLRP3 activity in T cells affects inflammatory responses in human autoinflammatory disease and in mouse models of inflammation and infection. Our results demonstrate that NLRP3 inflammasome activity is not confined to ?innate immune cells? but is an integral component of normal adaptive TH1 responses. äT helper 1 immunity requires complement-driven NLRP3 inflammasome acti(epmc).pdf DeepDyve Pubget Overpricing