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10.1161/JAHA.116.003486 http://scihub22266oqcxt.onion/10.1161/JAHA.116.003486 C5015386!5015386 !27385427     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27385427 &cmd=llinks): Failed to open stream: HTTP request failed! 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Plasma Fibroblast Growth Factor 23: Clinical Correlates and Association With Cardiovascular Disease and Mortality in the Framingham Heart Study |pdf=|usr=}}{{27385427 }} gab.com Text Plasma Fibroblast Growth Factor 23: Clinical Correlates and Association With Cardiovascular Disease and Mortality in the Framingham Heart Study JO: J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=27385427 #FOAvip BACKGROUND: Fibroblast growth factor 23 (FGF23) is emerging as a novel biomarker of bone metabolism, chronic kidney disease, and cardiovascular disease (CVD). However, its clinical correlates and potential predictive role in a community-based setting are incompletely understood. METHODS AND RESULTS: We evaluated participants of the Framingham Heart Study (seventh examination cycle of the Offspring cohort plus second examination cycle of the multiethnic Omni cohort) to identify clinical correlates of plasma FGF23 (N=3236) and examine its cross-sectional association with vascular function (N=2209), and longitudinal association with 10-year incidence of CVD (N=2823), and all-cause mortality (N=3223).Circulating FGF23 concentrations were positively related to African-American and Asian ethnicity, waist circumference, current smoking, serum glucose, history of CVD, and antihypertensive medication use; and negatively related to male sex, hormone replacement therapy, and estimated glomerular filtration rate. Multivariable-adjusted cross-sectional analyses showed no consistent association of FGF23 with vascular function measures. During a median follow-up time of 10.8 years, 347 incident CVD events and 412 deaths occurred. Multivariable-adjusted Cox regression models revealed a positive association of FGF23 with all-cause mortality (hazard ratio [HR] per SD increase, 1.31; 95% CI, 1.20-1.42), but not with incident CVD (HR per SD increase, 1.05; 95% CI, 0.94-1.17). CONCLUSIONS: In our large, community-based sample, FGF23 was associated with mortality risk, but not with vascular function or incident CVD. Twit Text FOAVip Plasma Fibroblast Growth Factor 23: Clinical Correlates and Association With Cardiovascular Disease and Mortality in the Framingham Heart Study ????J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=27385427 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27385427 #FOAvip English Wikipedia <ref>{{Cite pmid|27385427 }}</ref> Plasma Fibroblast Growth Factor 23: Clinical Correlates and Association With Cardiovascular Disease and Mortality in the Framingham Heart Study #MMPMID27385427 Haring R ; Enserro D ; Xanthakis V ; Mitchell GF ; Benjamin EJ ; Hamburg NM ; Sullivan L ; Nauck M ; Wallaschofski H ; Vasan RS J Am Heart Assoc 2016[Jul]; 5 (7 ): ä PMID27385427 show ga BACKGROUND: Fibroblast growth factor 23 (FGF23) is emerging as a novel biomarker of bone metabolism, chronic kidney disease, and cardiovascular disease (CVD). However, its clinical correlates and potential predictive role in a community-based setting are incompletely understood. METHODS AND RESULTS: We evaluated participants of the Framingham Heart Study (seventh examination cycle of the Offspring cohort plus second examination cycle of the multiethnic Omni cohort) to identify clinical correlates of plasma FGF23 (N=3236) and examine its cross-sectional association with vascular function (N=2209), and longitudinal association with 10-year incidence of CVD (N=2823), and all-cause mortality (N=3223).Circulating FGF23 concentrations were positively related to African-American and Asian ethnicity, waist circumference, current smoking, serum glucose, history of CVD, and antihypertensive medication use; and negatively related to male sex, hormone replacement therapy, and estimated glomerular filtration rate. Multivariable-adjusted cross-sectional analyses showed no consistent association of FGF23 with vascular function measures. During a median follow-up time of 10.8 years, 347 incident CVD events and 412 deaths occurred. Multivariable-adjusted Cox regression models revealed a positive association of FGF23 with all-cause mortality (hazard ratio [HR] per SD increase, 1.31; 95% CI, 1.20-1.42), but not with incident CVD (HR per SD increase, 1.05; 95% CI, 0.94-1.17). CONCLUSIONS: In our large, community-based sample, FGF23 was associated with mortality risk, but not with vascular function or incident CVD. |Biomarkers/blood [MESH] |Blood Glucose/analysis [MESH] |Blood Pressure [MESH] |Cardiovascular Diseases/*blood/epidemiology/mortality [MESH] |Female [MESH] |Fibroblast Growth Factor-23 [MESH] |Fibroblast Growth Factors/*blood [MESH] |Heart Rate [MESH] |Humans [MESH] |Incidence [MESH] |Longitudinal Studies [MESH] |Male [MESH] |Middle Aged [MESH] |Proportional Hazards Models [MESH] |Racial Groups/statistics & numerical data [MESH] |Risk Factors [MESH] |Sex Factors [MESH] |Smoking/blood [MESH]Plasma Fibroblast Growth Factor 23: Clinical Correlates and Associatio(epmc).pdf DeepDyve Pubget Overpricing