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10.1161/JAHA.116.004138 http://scihub22266oqcxt.onion/10.1161/JAHA.116.004138 C5015315!5015315!27528406     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27528406.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Am+Heart+Assoc 2016 ; 5 (8): ä Nephropedia Template TP {{tp|p=27528406|t=2016. Circulating MicroRNA?188, ?30a, and ?30e as Early Biomarkers for Contrast?Induced Acute Kidney Injury |pdf=|usr=}}{{27528406}} gab.com Text Circulating MicroRNA 188, 30a, and 30e as Early Biomarkers for Contrast Induced Acute Kidney Injury JO: J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=27528406 #FOAvip Background: Contrast?induced acute kidney injury (CI?AKI) is typically defined by an increase in serum creatinine after intravascular administration of contrast medium. Because creatinine is an unreliable indicator of acute changes in kidney function, we assessed whether circulating microRNAs (miRNAs) could serve as biomarkers for early detection of CI?AKI. Methods and Results: Using a rat model of CI?AKI, we first evaluated the miRNA profile of rat plasma and kidney. Three miRNA species with >1.5?fold increase in plasma samples of CI?AKI rats, including miRNA?188, miRNA?30a, and miRNA?30e, were selected as candidate miRNAs. Quantitative real?time polymerase chain reaction showed that these candidate miRNAs peaked in concentration around 4 hours after contrast medium exposure and were relatively renal?specific. We compared the plasma levels of these candidate miRNAs in 71 patients who underwent coronary angiography or percutaneous coronary intervention and developed CI?AKI with those of 71 matched controls. The plasma levels of the 3 candidate miRNAs were significantly elevated in the CI?AKI group as compared to the control group. Receiver operating characteristic analysis showed that these miRNAs significantly distinguished patients with CI?AKI from those without CI?AKI. MiRNA composites were highly accurate for CI?AKI prediction, as shown in maximized specificity by treble?positive miRNA composite or maximized Youden index by any?positive miRNA composite. Moreover, the selected miRNAs changes were associated with Mehran Risk Scores. Conclusions: Plasma levels of candidate miRNAs significantly distinguished patients with CI?AKI from those without CI?AKI. Thus, miRNAs are potential biomarkers for early detection of CI?AKI. Twit Text FOAVip Circulating MicroRNA 188, 30a, and 30e as Early Biomarkers for Contrast Induced Acute Kidney Injury ????J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=27528406 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27528406 #FOAvip English Wikipedia <ref>{{Cite pmid|27528406}}</ref> Circulating MicroRNA?188, ?30a, and ?30e as Early Biomarkers for Contrast?Induced Acute Kidney Injury #MMPMID27528406 Sun S; Zhang T; Ding D; Zhang W; Wang X; Sun Z; Hu L; Qin S; Shen L; He B J Am Heart Assoc 2016[Aug]; 5 (8): ä PMID27528406show ga Background: Contrast?induced acute kidney injury (CI?AKI) is typically defined by an increase in serum creatinine after intravascular administration of contrast medium. Because creatinine is an unreliable indicator of acute changes in kidney function, we assessed whether circulating microRNAs (miRNAs) could serve as biomarkers for early detection of CI?AKI. Methods and Results: Using a rat model of CI?AKI, we first evaluated the miRNA profile of rat plasma and kidney. Three miRNA species with >1.5?fold increase in plasma samples of CI?AKI rats, including miRNA?188, miRNA?30a, and miRNA?30e, were selected as candidate miRNAs. Quantitative real?time polymerase chain reaction showed that these candidate miRNAs peaked in concentration around 4 hours after contrast medium exposure and were relatively renal?specific. We compared the plasma levels of these candidate miRNAs in 71 patients who underwent coronary angiography or percutaneous coronary intervention and developed CI?AKI with those of 71 matched controls. The plasma levels of the 3 candidate miRNAs were significantly elevated in the CI?AKI group as compared to the control group. Receiver operating characteristic analysis showed that these miRNAs significantly distinguished patients with CI?AKI from those without CI?AKI. MiRNA composites were highly accurate for CI?AKI prediction, as shown in maximized specificity by treble?positive miRNA composite or maximized Youden index by any?positive miRNA composite. Moreover, the selected miRNAs changes were associated with Mehran Risk Scores. Conclusions: Plasma levels of candidate miRNAs significantly distinguished patients with CI?AKI from those without CI?AKI. Thus, miRNAs are potential biomarkers for early detection of CI?AKI. äCirculating MicroRNA?188, ?30a, and ?30e as Early Biomarkers for Contr(epmc).pdf DeepDyve Pubget Overpricing