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10.1038/srep30238 http://scihub22266oqcxt.onion/10.1038/srep30238 C5015017!5015017 !27605415     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27605415 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 30238 Nephropedia Template TP {{tp|p=27605415 |t=2016. YAP Subcellular Localization and Hippo Pathway Transcriptome Analysis in Pediatric Hepatocellular Carcinoma |pdf=|usr=}}{{27605415 }} gab.com Text YAP Subcellular Localization and Hippo Pathway Transcriptome Analysis in Pediatric Hepatocellular Carcinoma JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27605415 #FOAvip Pediatric hepatocellular carcinoma (HCC) is a rare tumor which is associated with an extremely high mortality rate due to lack of effective chemotherapy. Recently, the Hippo pathway and its transcriptional co-activator Yes-associated protein (YAP) have been shown to play a role in hepatocyte proliferation and development of HCC in animal models. Therefore, we sought to examine the activity of YAP and the expression of Hippo pathway components in tumor and non-neoplastic liver tissue from 7 pediatric patients with moderately differentiated HCC. None of the patients had underlying cirrhosis or viral hepatitis, which is commonly seen in adults with HCC. This highlights a major difference in the pathogenesis of HCC between children and adults. We found a statistically significant increase in YAP nuclear localization in 100% of tumors. YAP target gene (CCNE1, CTGF, Cyr61) mRNA expression was also increased in the tumors that had the most significant increase in YAP nuclear localization. Based on Ki67 co-localization studies YAP nuclear localization was not simply a marker of proliferation. Our results demonstrate a clear increase in YAP activity in moderately differentiated pediatric HCC, providing evidence that it may play an important role in tumor survival and propagation. Twit Text FOAVip YAP Subcellular Localization and Hippo Pathway Transcriptome Analysis in Pediatric Hepatocellular Carcinoma ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27605415 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27605415 #FOAvip English Wikipedia <ref>{{Cite pmid|27605415 }}</ref> YAP Subcellular Localization and Hippo Pathway Transcriptome Analysis in Pediatric Hepatocellular Carcinoma #MMPMID27605415 LaQuaglia MJ ; Grijalva JL ; Mueller KA ; Perez-Atayde AR ; Kim HB ; Sadri-Vakili G ; Vakili K Sci Rep 2016[Sep]; 6 (ä): 30238 PMID27605415 show ga Pediatric hepatocellular carcinoma (HCC) is a rare tumor which is associated with an extremely high mortality rate due to lack of effective chemotherapy. Recently, the Hippo pathway and its transcriptional co-activator Yes-associated protein (YAP) have been shown to play a role in hepatocyte proliferation and development of HCC in animal models. Therefore, we sought to examine the activity of YAP and the expression of Hippo pathway components in tumor and non-neoplastic liver tissue from 7 pediatric patients with moderately differentiated HCC. None of the patients had underlying cirrhosis or viral hepatitis, which is commonly seen in adults with HCC. This highlights a major difference in the pathogenesis of HCC between children and adults. We found a statistically significant increase in YAP nuclear localization in 100% of tumors. YAP target gene (CCNE1, CTGF, Cyr61) mRNA expression was also increased in the tumors that had the most significant increase in YAP nuclear localization. Based on Ki67 co-localization studies YAP nuclear localization was not simply a marker of proliferation. Our results demonstrate a clear increase in YAP activity in moderately differentiated pediatric HCC, providing evidence that it may play an important role in tumor survival and propagation. |*Gene Expression Regulation, Neoplastic [MESH] |*Transcriptome [MESH] |Adaptor Proteins, Signal Transducing/*genetics/metabolism [MESH] |Adolescent [MESH] |Carcinoma, Hepatocellular/*genetics/metabolism/pathology/surgery [MESH] |Cell Nucleus/metabolism/pathology [MESH] |Child [MESH] |Connective Tissue Growth Factor/genetics/metabolism [MESH] |Cyclin E/genetics/metabolism [MESH] |Cysteine-Rich Protein 61/genetics/metabolism [MESH] |Hepatocytes/metabolism/pathology [MESH] |Hippo Signaling Pathway [MESH] |Humans [MESH] |Infant [MESH] |Ki-67 Antigen/genetics/metabolism [MESH] |Liver Neoplasms/*genetics/metabolism/pathology/surgery [MESH] |Male [MESH] |Neoplasm Grading [MESH] |Oncogene Proteins/genetics/metabolism [MESH] |Phosphoproteins/*genetics/metabolism [MESH] |Protein Serine-Threonine Kinases/genetics/metabolism [MESH] |RNA, Messenger/genetics/metabolism [MESH] |Signal Transduction [MESH] |Transcription Factors [MESH]YAP Subcellular Localization and Hippo Pathway Transcriptome Analysis (epmc).pdf DeepDyve Pubget Overpricing