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2016 ; 2016
(ä): 8634603
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Role of Macrophages in the Repair Process during the Tissue Migrating and
Resident Helminth Infections
#MMPMID27648452
Faz-López B
; Morales-Montor J
; Terrazas LI
Biomed Res Int
2016[]; 2016
(ä): 8634603
PMID27648452
show ga
The Th1/Th2/Th17 balance is a fundamental feature in the regulation of the
inflammatory microenvironment during helminth infections, and an imbalance in
this paradigm greatly contributes to inflammatory disorders. In some cases of
helminthiasis, an initial Th1 response could occur during the early phases of
infection (acute), followed by a Th2 response that prevails in chronic
infections. During the late phase of infection, alternatively activated
macrophages (AAMs) are important to counteract the inflammation caused by the
Th1/Th17 response and larval migration, limiting damage and repairing the tissue
affected. Macrophages are the archetype of phagocytic cells, with the primary
role of pathogen destruction and antigen presentation. Nevertheless, other
subtypes of macrophages have been described with important roles in tissue repair
and immune regulation. These types of macrophages challenge the classical view of
macrophages activated by an inflammatory response. The role of these subtypes of
macrophages during helminthiasis is a controversial topic in immunoparasitology.
Here, we analyze some of the studies regarding the role of AAMs in tissue repair
during the tissue migration of helminths.