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2016 ; 7
(5
): 395-406
Nephropedia Template TP
gab.com Text
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English Wikipedia
Systematic Review and Meta-Analysis of the Efficacy of Interleukin-1 Receptor
Antagonist in Animal Models of Stroke: an Update
#MMPMID27526101
McCann SK
; Cramond F
; Macleod MR
; Sena ES
Transl Stroke Res
2016[Oct]; 7
(5
): 395-406
PMID27526101
show ga
Interleukin-1 receptor antagonist (IL-1 RA) is an anti-inflammatory protein used
clinically to treat rheumatoid arthritis and is considered a promising candidate
therapy for stroke. Here, we sought to update the existing systematic review and
meta-analysis of IL-1 RA in models of ischaemic stroke, published in 2009, to
assess efficacy, the range of circumstances in which efficacy has been tested and
whether the data appear to be confounded due to reported study quality and
publication bias. We included 25 sources of data, 11 of which were additional to
the original review. Overall, IL-1 RA reduced infarct volume by 36.2 % (95 %
confidence interval 31.6-40.7, n?=?76 comparisons from 1283 animals). Assessments
for publication bias suggest 30 theoretically missing studies which reduce
efficacy to 21.9 % (17.3-26.4). Efficacy was higher where IL-1 RA was
administered directly into the ventricles rather than peripherally, and studies
not reporting allocation concealment during the induction of ischaemia reported
larger treatment effects. The preclinical data supporting IL-1 RA as a candidate
therapy for ischaemic stroke have improved. The reporting of measures to reduce
the risk of bias has improved substantially in this update, and studies now
include the use of animals with relevant co-morbidities.
|*Disease Models, Animal
[MESH]
|Animals
[MESH]
|Humans
[MESH]
|Interleukin 1 Receptor Antagonist Protein/*therapeutic use
[MESH]
free
free
free
