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10.1016/j.jaci.2016.02.030 http://scihub22266oqcxt.onion/10.1016/j.jaci.2016.02.030 C5014699!5014699!27177780     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Allergy+Clin+Immunol 2016 ; 138 (3): 801-811.e9 Nephropedia Template TP {{tp|p=27177780|t=2016. IL-4 Production by Group 2 Innate Lymphoid cells Promotes Food Allergy by Blocking Regulatory T cell Function |pdf=|usr=}}{{27177780}} gab.com Text IL-4 Production by Group 2 Innate Lymphoid cells Promotes Food Allergy by Blocking Regulatory T cell Function JO: J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27177780 #FOAvip Background: Food allergy is a major health issue, but its pathogenesis remains obscure. Group 2 innate lymphoid cells (ILC2) promote allergic inflammation. However their role in food allergy is largely unknown. Objective: We sought to investigate the role of ILC2 in food allergy. Methods: Food allergy-prone mice with a gain of function mutation in the IL-4 receptor a chain (Il4raF709) were orally sensitized with food allergens and the ILC2 compartment was analyzed. The requirement for ILC2 in food allergy was investigated using Il4raF709, IL-33 receptor deficient (Il1rl1?/?), IL-13 (Il13?/?) and IL-4 (Il4?/?) deficient mice and by adoptive transfers of in vitro-expanded ILC2. Direct effects of ILC2 on regulatory T (Treg) cells and mast cells were analyzed in co-culture experiments. Treg cell control of ILC2 was assessed in vitro and in vivo. Results: Food allergic Il4raF709 mice exhibit increased numbers of ILC2. IL-4 secretion by ILC2 contributes to the allergic response by reducing allergen-specific Treg cells and activating mast cells. IL-33 receptor deficiency in Il4raF709Il1rl1?/? mice protects against allergen sensitization and anaphylaxis while reducing ILC2 induction. Adoptive transfer of WT and Il13?/? but not Il4?/? ILC2 restored sensitization in Il4raF709 Il1rl1?/? mice. Treg cells suppress ILC2 in vitro and in vivo. Conclusion: IL-4 production by IL-33-stimulated ILC2 blocks the generation of allergen-specific Treg cells and favors food allergy. Strategies to block ILC2 activation or the IL-33:IL-33R pathway may lead to innovative therapies in food allergy. Twit Text FOAVip IL-4 Production by Group 2 Innate Lymphoid cells Promotes Food Allergy by Blocking Regulatory T cell Function ????J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27177780 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27177780 #FOAvip English Wikipedia <ref>{{Cite pmid|27177780}}</ref> IL-4 Production by Group 2 Innate Lymphoid cells Promotes Food Allergy by Blocking Regulatory T cell Function #MMPMID27177780 Rivas MN; Burton OT; Oettgen HC; Chatila T J Allergy Clin Immunol 2016[Sep]; 138 (3): 801-811.e9 PMID27177780show ga Background: Food allergy is a major health issue, but its pathogenesis remains obscure. Group 2 innate lymphoid cells (ILC2) promote allergic inflammation. However their role in food allergy is largely unknown. Objective: We sought to investigate the role of ILC2 in food allergy. Methods: Food allergy-prone mice with a gain of function mutation in the IL-4 receptor a chain (Il4raF709) were orally sensitized with food allergens and the ILC2 compartment was analyzed. The requirement for ILC2 in food allergy was investigated using Il4raF709, IL-33 receptor deficient (Il1rl1?/?), IL-13 (Il13?/?) and IL-4 (Il4?/?) deficient mice and by adoptive transfers of in vitro-expanded ILC2. Direct effects of ILC2 on regulatory T (Treg) cells and mast cells were analyzed in co-culture experiments. Treg cell control of ILC2 was assessed in vitro and in vivo. Results: Food allergic Il4raF709 mice exhibit increased numbers of ILC2. IL-4 secretion by ILC2 contributes to the allergic response by reducing allergen-specific Treg cells and activating mast cells. IL-33 receptor deficiency in Il4raF709Il1rl1?/? mice protects against allergen sensitization and anaphylaxis while reducing ILC2 induction. Adoptive transfer of WT and Il13?/? but not Il4?/? ILC2 restored sensitization in Il4raF709 Il1rl1?/? mice. Treg cells suppress ILC2 in vitro and in vivo. Conclusion: IL-4 production by IL-33-stimulated ILC2 blocks the generation of allergen-specific Treg cells and favors food allergy. Strategies to block ILC2 activation or the IL-33:IL-33R pathway may lead to innovative therapies in food allergy. äIL-4 Production by Group 2 Innate Lymphoid cells Promotes Food Allergy(epmc).pdf DeepDyve Pubget Overpricing