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10.1016/j.jaci.2016.02.030 http://scihub22266oqcxt.onion/10.1016/j.jaci.2016.02.030 C5014699!5014699 !27177780     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27177780 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Allergy+Clin+Immunol 2016 ; 138 (3 ): 801-811.e9 Nephropedia Template TP {{tp|p=27177780 |t=2016. IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function |pdf=|usr=}}{{27177780 }} gab.com Text IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function JO: J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27177780 #FOAvip BACKGROUND: Food allergy is a major health issue, but its pathogenesis remains obscure. Group 2 innate lymphoid cells (ILC2s) promote allergic inflammation. However their role in food allergy is largely unknown. OBJECTIVE: We sought to investigate the role of ILC2s in food allergy. METHODS: Food allergy-prone mice with a gain-of-function mutation in the IL-4 receptor ? chain (Il4raF709) were orally sensitized with food allergens, and the ILC2 compartment was analyzed. The requirement for ILC2s in food allergy was investigated by using Il4raF709, IL-33 receptor-deficient (Il1rl1(-/-)), IL-13-deficient (Il13(-/-)), and IL-4-deficient (Il4(-/-)) mice and by adoptive transfer of in vitro-expanded ILC2s. Direct effects of ILC2s on regulatory T (Treg) cells and mast cells were analyzed in coculture experiments. Treg cell control of ILC2s was assessed in vitro and in vivo. RESULTS: Il4raF709 mice with food allergy exhibit increased numbers of ILC2s. IL-4 secretion by ILC2s contributes to the allergic response by reducing allergen-specific Treg cell and activating mast cell counts. IL-33 receptor deficiency in Il4raF709 Il1rl1(-/-) mice protects against allergen sensitization and anaphylaxis while reducing ILC2 induction. Adoptive transfer of wild-type and Il13(-/-) but not Il4(-/-) ILC2s restored sensitization in Il4raF709 Il1rl1(-/-) mice. Treg cells suppress ILC2s in vitro and in vivo. CONCLUSION: IL-4 production by IL-33-stimulated ILC2s blocks the generation of allergen-specific Treg cells and favors food allergy. Strategies to block ILC2 activation or the IL-33/IL-33 receptor pathway can lead to innovative therapies in the treatment of food allergy. Twit Text FOAVip IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function ????J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27177780 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27177780 #FOAvip English Wikipedia <ref>{{Cite pmid|27177780 }}</ref> IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function #MMPMID27177780 Noval Rivas M ; Burton OT ; Oettgen HC ; Chatila T J Allergy Clin Immunol 2016[Sep]; 138 (3 ): 801-811.e9 PMID27177780 show ga BACKGROUND: Food allergy is a major health issue, but its pathogenesis remains obscure. Group 2 innate lymphoid cells (ILC2s) promote allergic inflammation. However their role in food allergy is largely unknown. OBJECTIVE: We sought to investigate the role of ILC2s in food allergy. METHODS: Food allergy-prone mice with a gain-of-function mutation in the IL-4 receptor ? chain (Il4raF709) were orally sensitized with food allergens, and the ILC2 compartment was analyzed. The requirement for ILC2s in food allergy was investigated by using Il4raF709, IL-33 receptor-deficient (Il1rl1(-/-)), IL-13-deficient (Il13(-/-)), and IL-4-deficient (Il4(-/-)) mice and by adoptive transfer of in vitro-expanded ILC2s. Direct effects of ILC2s on regulatory T (Treg) cells and mast cells were analyzed in coculture experiments. Treg cell control of ILC2s was assessed in vitro and in vivo. RESULTS: Il4raF709 mice with food allergy exhibit increased numbers of ILC2s. IL-4 secretion by ILC2s contributes to the allergic response by reducing allergen-specific Treg cell and activating mast cell counts. IL-33 receptor deficiency in Il4raF709 Il1rl1(-/-) mice protects against allergen sensitization and anaphylaxis while reducing ILC2 induction. Adoptive transfer of wild-type and Il13(-/-) but not Il4(-/-) ILC2s restored sensitization in Il4raF709 Il1rl1(-/-) mice. Treg cells suppress ILC2s in vitro and in vivo. CONCLUSION: IL-4 production by IL-33-stimulated ILC2s blocks the generation of allergen-specific Treg cells and favors food allergy. Strategies to block ILC2 activation or the IL-33/IL-33 receptor pathway can lead to innovative therapies in the treatment of food allergy. |Animals [MESH] |Cells, Cultured [MESH] |Coculture Techniques [MESH] |Food Hypersensitivity/*immunology [MESH] |Immunity, Innate [MESH] |Interleukin-4/genetics/*immunology [MESH] |Lymphocytes/*immunology [MESH] |Mast Cells/*immunology [MESH]IL-4 production by group 2 innate lymphoid cells promotes food allergy(epmc).pdf DeepDyve Pubget Overpricing