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10.1016/j.jaci.2015.12.1330 http://scihub22266oqcxt.onion/10.1016/j.jaci.2015.12.1330 C5014627!5014627!26971690     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Allergy+Clin+Immunol 2016 ; 138 (3): 825-38 Nephropedia Template TP {{tp|p=26971690|t=2016. Clonal expansion of CD4+ Cytotoxic T Lymphocytes in IgG4-related disease |pdf=|usr=}}{{26971690}} gab.com Text Clonal expansion of CD4+ Cytotoxic T Lymphocytes in IgG4-related disease JO: J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26971690 #FOAvip Background: IgG4-related disease (IgG4-RD) is a systemic condition of unknown etiology, characterized by highly fibrotic lesions with dense lymphoplasmacytic infiltrates. CD4+ T cells constitute the major inflammatory cell population in IgG4-RD lesions. Objective: We used an unbiased approach to characterize CD4+ T cell subsets in IgG4-RD subjects based on their clonal expansion and their ability to infiltrate affected tissue sites. Methods: We used flow cytometry to identify CD4+ effector/memory T cells (TEM) in a cohort of 101 IgG4-related disease (IgG4-RD) patients. These expanded cells were characterized by gene expression analysis and flow cytometry. Next-generation sequencing of the T cell receptor ? chain gene was performed on CD4+SLAMF7+ CTLs and CD4+GATA3+ TH2 cells in a subset of patients to identify their clonality. Tissue infiltration by specific T cells was examined using quantitative multi-color imaging. Results: CD4+ effector/memory T cells with a cytolytic phenotype were expanded in IgG4-RD patients. Next-generation sequencing revealed prominent clonal expansions of these CD4+CTLs but not CD4+GATA3+ memory TH2 cells in subjects with IgG4-RD. The dominant T cells infiltrating a range of inflamed IgG4-RD tissue sites were clonally-expanded CD4+CTLs that expressed SLAMF7, granzyme A, IL-1?, and TGF-?1. Clinical remission induced by rituximab-mediated B cell depletion was associated with a reduction in disease-associated CD4+ CTLs Conclusions: IgG4-RD is prominently linked to clonally-expanded, IL-1?, and TGF- ?1 secreting, CD4+ CTLs in peripheral blood as well as in inflammatory tissue lesions. These active, terminally-differentiated, cytokine-secreting effector CD4+ T cells are now linked to a human disease characterized by chronic inflammation and fibrosis. Twit Text FOAVip Clonal expansion of CD4+ Cytotoxic T Lymphocytes in IgG4-related disease ????J Allergy Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26971690 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26971690 #FOAvip English Wikipedia <ref>{{Cite pmid|26971690}}</ref> Clonal expansion of CD4+ Cytotoxic T Lymphocytes in IgG4-related disease #MMPMID26971690 Mattoo H; Mahajan VS; Maehara T; Deshpande V; Della-Torre E; Wallace ZS; Kulikova M; Drijvers JM; Daccache J; Carruthers MN; Castellino F; Stone JR; Stone JH; Pillai S J Allergy Clin Immunol 2016[Sep]; 138 (3): 825-38 PMID26971690show ga Background: IgG4-related disease (IgG4-RD) is a systemic condition of unknown etiology, characterized by highly fibrotic lesions with dense lymphoplasmacytic infiltrates. CD4+ T cells constitute the major inflammatory cell population in IgG4-RD lesions. Objective: We used an unbiased approach to characterize CD4+ T cell subsets in IgG4-RD subjects based on their clonal expansion and their ability to infiltrate affected tissue sites. Methods: We used flow cytometry to identify CD4+ effector/memory T cells (TEM) in a cohort of 101 IgG4-related disease (IgG4-RD) patients. These expanded cells were characterized by gene expression analysis and flow cytometry. Next-generation sequencing of the T cell receptor ? chain gene was performed on CD4+SLAMF7+ CTLs and CD4+GATA3+ TH2 cells in a subset of patients to identify their clonality. Tissue infiltration by specific T cells was examined using quantitative multi-color imaging. Results: CD4+ effector/memory T cells with a cytolytic phenotype were expanded in IgG4-RD patients. Next-generation sequencing revealed prominent clonal expansions of these CD4+CTLs but not CD4+GATA3+ memory TH2 cells in subjects with IgG4-RD. The dominant T cells infiltrating a range of inflamed IgG4-RD tissue sites were clonally-expanded CD4+CTLs that expressed SLAMF7, granzyme A, IL-1?, and TGF-?1. Clinical remission induced by rituximab-mediated B cell depletion was associated with a reduction in disease-associated CD4+ CTLs Conclusions: IgG4-RD is prominently linked to clonally-expanded, IL-1?, and TGF- ?1 secreting, CD4+ CTLs in peripheral blood as well as in inflammatory tissue lesions. These active, terminally-differentiated, cytokine-secreting effector CD4+ T cells are now linked to a human disease characterized by chronic inflammation and fibrosis. äClonal expansion of CD4+ Cytotoxic T Lymphocytes in IgG4-related disea(epmc).pdf DeepDyve Pubget Overpricing