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10.1002/adma.201601498 http://scihub22266oqcxt.onion/10.1002/adma.201601498 C5014563!5014563!27255214     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27255214.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Adv+Mater 2016 ; 28 (34): 7340-64 Nephropedia Template TP {{tp|p=27255214|t=2016. Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization |pdf=|usr=}}{{27255214}} gab.com Text Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization JO: Adv Mater http://www.kidney.de/pget.php?&tw=1&pmid=27255214 #FOAvip Targeted delivery of therapeutic agent is an important way to improve therapeutic index and reduce side effects. To design nanoparticles for targeted delivery, both enhanced tumor tissue accumulation/retention and enhanced cellular internalization should be considered simultaneously. Unfortunately, so far, there have been very few nanoparticles with immutable structures can achieve this goal efficiently. Hierarchical targeting, a novel targeting strategy based on stimuli responsiveness, shows good potential to enhance both tumor tissue accumulation/retention and cellular internalization. In this review, we will introduce recent design and development of hierarchical targeting nanoplatforms, which are based on changeable particle sizes, switchable surface charges and activatable surface ligands. In general, the targeting moieties in these nanoplatforms are not activated during blood circulation for efficient tumor tissue accumulation and then re-activated by certain internal or external stimuli in tumor microenvironment for enhanced cellular internalization. Twit Text FOAVip Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization ????Adv Mater http://www.kidney.de/pget.php?&tw=1&pmid=27255214 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27255214 #FOAvip English Wikipedia <ref>{{Cite pmid|27255214}}</ref> Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization #MMPMID27255214 Wang S; Huang P; Chen X Adv Mater 2016[Sep]; 28 (34): 7340-64 PMID27255214show ga Targeted delivery of therapeutic agent is an important way to improve therapeutic index and reduce side effects. To design nanoparticles for targeted delivery, both enhanced tumor tissue accumulation/retention and enhanced cellular internalization should be considered simultaneously. Unfortunately, so far, there have been very few nanoparticles with immutable structures can achieve this goal efficiently. Hierarchical targeting, a novel targeting strategy based on stimuli responsiveness, shows good potential to enhance both tumor tissue accumulation/retention and cellular internalization. In this review, we will introduce recent design and development of hierarchical targeting nanoplatforms, which are based on changeable particle sizes, switchable surface charges and activatable surface ligands. In general, the targeting moieties in these nanoplatforms are not activated during blood circulation for efficient tumor tissue accumulation and then re-activated by certain internal or external stimuli in tumor microenvironment for enhanced cellular internalization. äHierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation(epmc).pdf DeepDyve Pubget Overpricing