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10.7554/eLife.18413 http://scihub22266oqcxt.onion/10.7554/eLife.18413 C5014549!5014549!27602576     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2016 ; 5 (ä): ä Nephropedia Template TP {{tp|p=27602576|t=2016. Distinct stages in stress granule assembly and disassembly |pdf=|usr=}}{{27602576}} gab.com Text Distinct stages in stress granule assembly and disassembly JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=27602576 #FOAvip Stress granules are non-membrane bound RNA-protein (RNP) assemblies that form when translation initiation is limited and contain a biphasic structure with stable core structures surrounded by a less concentrated shell. The order of assembly and disassembly of these two structures remains unknown. Time course analysis of granule assembly suggests that core formation is an early event in granule assembly. Stress granule disassembly is also a stepwise process with shell dissipation followed by core clearance. Perturbations that alter liquid-liquid phase separations (LLPS) driven by intrinsically disordered protein regions (IDR) of RNA binding proteins in vitro have the opposite effect on stress granule assembly in vivo. Taken together, these observations argue that stress granules assemble through a multistep process initiated by stable assembly of untranslated mRNPs into core structures, which could provide sufficient high local concentrations to allow for a localized LLPS driven by IDRs on RNA binding proteins.DOI:http://dx.doi.org/10.7554/eLife.18413.001 Twit Text FOAVip Distinct stages in stress granule assembly and disassembly ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=27602576 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27602576 #FOAvip English Wikipedia <ref>{{Cite pmid|27602576}}</ref> Distinct stages in stress granule assembly and disassembly #MMPMID27602576 Wheeler JR; Matheny T; Jain S; Abrisch R; Parker R eLife 2016[]; 5 (ä): ä PMID27602576show ga Stress granules are non-membrane bound RNA-protein (RNP) assemblies that form when translation initiation is limited and contain a biphasic structure with stable core structures surrounded by a less concentrated shell. The order of assembly and disassembly of these two structures remains unknown. Time course analysis of granule assembly suggests that core formation is an early event in granule assembly. Stress granule disassembly is also a stepwise process with shell dissipation followed by core clearance. Perturbations that alter liquid-liquid phase separations (LLPS) driven by intrinsically disordered protein regions (IDR) of RNA binding proteins in vitro have the opposite effect on stress granule assembly in vivo. Taken together, these observations argue that stress granules assemble through a multistep process initiated by stable assembly of untranslated mRNPs into core structures, which could provide sufficient high local concentrations to allow for a localized LLPS driven by IDRs on RNA binding proteins.DOI:http://dx.doi.org/10.7554/eLife.18413.001 äDistinct stages in stress granule assembly and disassembly (epmc).pdf DeepDyve Pubget Overpricing