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10.1038/nrm3853 http://scihub22266oqcxt.onion/10.1038/nrm3853 C5014371!5014371!25118718     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Mol+Cell+Biol 2014 ; 15 (9): 615-28 Nephropedia Template TP {{tp|p=25118718|t=2014. Bidirectional cargo transport: Moving beyond tug-of-war |pdf=|usr=}}{{25118718}} gab.com Text Bidirectional cargo transport: Moving beyond tug-of-war JO: Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25118718 #FOAvip Vesicles, organelles and other intracellular cargo are transported by kinesin and dynein motors, which move in opposite directions along microtubules. This bidirectional cargo movement is frequently described as a ?tug-of-war? between oppositely-directed motors attached to the same cargo. However, although many experimental and modeling studies support the tug-of-war paradigm, numerous knockout and inhibition studies in a variety of systems have found that inhibiting one motor leads to diminished motility in both directions, which is a ?paradox of codependence? that challenges it. In an effort to resolve this paradox, three classes of bidirectional transport models, termed microtubule tethering, mechanical activation, and steric disinhibition, are proposed and a general mathematical modeling framework for bidirectional cargo transport is put forward to guide future experiments. Twit Text FOAVip Bidirectional cargo transport: Moving beyond tug-of-war ????Nat Rev Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25118718 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25118718 #FOAvip English Wikipedia <ref>{{Cite pmid|25118718}}</ref> Bidirectional cargo transport: Moving beyond tug-of-war #MMPMID25118718 Hancock WO Nat Rev Mol Cell Biol 2014[Sep]; 15 (9): 615-28 PMID25118718show ga Vesicles, organelles and other intracellular cargo are transported by kinesin and dynein motors, which move in opposite directions along microtubules. This bidirectional cargo movement is frequently described as a ?tug-of-war? between oppositely-directed motors attached to the same cargo. However, although many experimental and modeling studies support the tug-of-war paradigm, numerous knockout and inhibition studies in a variety of systems have found that inhibiting one motor leads to diminished motility in both directions, which is a ?paradox of codependence? that challenges it. In an effort to resolve this paradox, three classes of bidirectional transport models, termed microtubule tethering, mechanical activation, and steric disinhibition, are proposed and a general mathematical modeling framework for bidirectional cargo transport is put forward to guide future experiments. äBidirectional cargo transport: Moving beyond tug-of-war (epmc).pdf DeepDyve Pubget Overpricing