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10.1093/carcin/bgw005 http://scihub22266oqcxt.onion/10.1093/carcin/bgw005 C5014091!5014091!26762229     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Carcinogenesis 2016 ; 37 (3): 223-32 Nephropedia Template TP {{tp|p=26762229|t=2016. Mucins and Wnt/?-catenin signaling in gastrointestinal cancers: an unholy nexus |pdf=|usr=}}{{26762229}} gab.com Text Mucins and Wnt/ -catenin signaling in gastrointestinal cancers: an unholy nexus JO: Carcinogenesis http://www.kidney.de/pget.php?&tw=1&pmid=26762229 #FOAvip The Wnt/?-catenin signaling pathway is indispensable for embryonic development, maintenance of adult tissue homeostasis and repair of epithelial injury. Unsurprisingly, aberrations in this pathway occur frequently in many cancers and often result in increased nuclear ?-catenin. While mutations in key pathway members, such as ?-catenin and adenomatous polyposis coli, are early and frequent occurrences in most colorectal cancers (CRC), mutations in canonical pathway members are rare in pancreatic ductal adenocarcinoma (PDAC). Instead, in the majority of PDACs, indirect mechanisms such as promoter methylation, increased ligand secretion and decreased pathway inhibitor secretion work in concert to promote aberrant cytosolic/nuclear localization of ?-catenin. Concomitant with alterations in ?-catenin localization, changes in mucin expression and localization have been documented in multiple malignancies. Indeed, numerous studies over the years suggest an intricate and mutually regulatory relationship between mucins (MUCs) and ?-catenin. In the current review, we summarize several studies that describe the relationship between mucins and ?-catenin in gastrointestinal malignancies, with particular emphasis upon colorectal and pancreatic cancer. Twit Text FOAVip Mucins and Wnt/ -catenin signaling in gastrointestinal cancers: an unholy nexus ????Carcinogenesis http://www.kidney.de/pget.php?&tw=1&pmid=26762229 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26762229 #FOAvip English Wikipedia <ref>{{Cite pmid|26762229}}</ref> Mucins and Wnt/?-catenin signaling in gastrointestinal cancers: an unholy nexus #MMPMID26762229 Pai P; Rachagani S; Dhawan P; Batra SK Carcinogenesis 2016[Mar]; 37 (3): 223-32 PMID26762229show ga The Wnt/?-catenin signaling pathway is indispensable for embryonic development, maintenance of adult tissue homeostasis and repair of epithelial injury. Unsurprisingly, aberrations in this pathway occur frequently in many cancers and often result in increased nuclear ?-catenin. While mutations in key pathway members, such as ?-catenin and adenomatous polyposis coli, are early and frequent occurrences in most colorectal cancers (CRC), mutations in canonical pathway members are rare in pancreatic ductal adenocarcinoma (PDAC). Instead, in the majority of PDACs, indirect mechanisms such as promoter methylation, increased ligand secretion and decreased pathway inhibitor secretion work in concert to promote aberrant cytosolic/nuclear localization of ?-catenin. Concomitant with alterations in ?-catenin localization, changes in mucin expression and localization have been documented in multiple malignancies. Indeed, numerous studies over the years suggest an intricate and mutually regulatory relationship between mucins (MUCs) and ?-catenin. In the current review, we summarize several studies that describe the relationship between mucins and ?-catenin in gastrointestinal malignancies, with particular emphasis upon colorectal and pancreatic cancer. äMucins and Wnt/?-catenin signaling in gastrointestinal cancers: an unh(epmc).pdf DeepDyve Pubget Overpricing