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10.1016/j.str.2016.06.020 http://scihub22266oqcxt.onion/10.1016/j.str.2016.06.020 C5014086!5014086 !27524201     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27524201 &cmd=llinks): Failed to open stream: HTTP request failed! 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Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Ternary Complex Formation with LRP6 and Dickkopf |pdf=|usr=}}{{27524201 }} gab.com Text Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Ternary Complex Formation with LRP6 and Dickkopf JO: Structure http://www.kidney.de/pget.php?&tw=1&pmid=27524201 #FOAvip Kremen 1 and 2 have been identified as co-receptors for Dickkopf (Dkk) proteins, hallmark secreted antagonists of canonical Wnt signaling. We present here three crystal structures of the ectodomain of human Kremen1 (KRM1ECD) at resolutions between 1.9 and 3.2 Å. KRM1ECD emerges as a rigid molecule with tight interactions stabilizing a triangular arrangement of its Kringle, WSC, and CUB structural domains. The structures reveal an unpredicted homology of the WSC domain to hepatocyte growth factor. We further report the general architecture of the ternary complex formed by the Wnt co-receptor Lrp5/6, Dkk, and Krm, determined from a low-resolution complex crystal structure between ?-propeller/EGF repeats (PE) 3 and 4 of the Wnt co-receptor LRP6 (LRP6PE3PE4), the cysteine-rich domain 2 (CRD2) of DKK1, and KRM1ECD. DKK1CRD2 is sandwiched between LRP6PE3 and KRM1Kringle-WSC. Modeling studies supported by surface plasmon resonance suggest a direct interaction site between Krm1CUB and Lrp6PE2. Twit Text FOAVip Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Ternary Complex Formation with LRP6 and Dickkopf ????Structure http://www.kidney.de/pget.php?&tw=1&pmid=27524201 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27524201 #FOAvip English Wikipedia <ref>{{Cite pmid|27524201 }}</ref> Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Ternary Complex Formation with LRP6 and Dickkopf #MMPMID27524201 Zebisch M ; Jackson VA ; Zhao Y ; Jones EY Structure 2016[Sep]; 24 (9 ): 1599-605 PMID27524201 show ga Kremen 1 and 2 have been identified as co-receptors for Dickkopf (Dkk) proteins, hallmark secreted antagonists of canonical Wnt signaling. We present here three crystal structures of the ectodomain of human Kremen1 (KRM1ECD) at resolutions between 1.9 and 3.2 Å. KRM1ECD emerges as a rigid molecule with tight interactions stabilizing a triangular arrangement of its Kringle, WSC, and CUB structural domains. The structures reveal an unpredicted homology of the WSC domain to hepatocyte growth factor. We further report the general architecture of the ternary complex formed by the Wnt co-receptor Lrp5/6, Dkk, and Krm, determined from a low-resolution complex crystal structure between ?-propeller/EGF repeats (PE) 3 and 4 of the Wnt co-receptor LRP6 (LRP6PE3PE4), the cysteine-rich domain 2 (CRD2) of DKK1, and KRM1ECD. DKK1CRD2 is sandwiched between LRP6PE3 and KRM1Kringle-WSC. Modeling studies supported by surface plasmon resonance suggest a direct interaction site between Krm1CUB and Lrp6PE2. |Amino Acid Motifs [MESH] |Binding Sites [MESH] |Cloning, Molecular [MESH] |Crystallography, X-Ray [MESH] |Gene Expression [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Intercellular Signaling Peptides and Proteins/*chemistry/genetics/metabolism [MESH] |Low Density Lipoprotein Receptor-Related Protein-6/*chemistry/genetics/metabolism [MESH] |Membrane Proteins/*chemistry/genetics/metabolism [MESH] |Models, Molecular [MESH] |Protein Binding [MESH] |Protein Conformation, alpha-Helical [MESH] |Protein Conformation, beta-Strand [MESH] |Protein Interaction Domains and Motifs [MESH] |Protein Multimerization [MESH]Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Tern(epmc).pdf DeepDyve Pubget Overpricing