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10.1080/15476286.2016.1203504 http://scihub22266oqcxt.onion/10.1080/15476286.2016.1203504 C5014007!5014007!27351916     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       RNA+Biol 2016 ; 13 (9): 760-5 Nephropedia Template TP {{tp|p=27351916|t=2016. mRNA modifications: Dynamic regulators of gene expression?|pdf=|usr=}}{{27351916}} gab.com Text mRNA modifications: Dynamic regulators of gene expression JO: RNA Biol http://www.kidney.de/pget.php?&tw=1&pmid=27351916 #FOAvip The expression of a gene is a tightly regulated process and is exerted by a myriad of different mechanisms. Recently, RNA modifications located in coding sequences of mRNAs, have been identified as potential regulators of gene expression. N6-methyladenosine (m6A), 5-methylcytosine (m5C), pseudouridine (?) and N1-methyladenosine (m1A) have been found within open reading frames of mRNAs. The presence of these mRNA modifications has been implicated to modulate the fate of an mRNA, ranging from maturation to its translation and even degradation. However, many aspects concerning the biological functions of mRNA modifications remain elusive. Recently, systematic in vitro studies allowed a first glimpse of the direct interplay of mRNA modifications and the efficiency and fidelity of ribosomal translation. It thereby became evident that the effects of mRNA modifications were, astonishingly versatile, depending on the type, position or sequence context. The incorporation of a single modification could either prematurely terminate protein synthesis, reduce the peptide yield or alter the amino acid sequence identity. These results implicate that mRNA modifications are a powerful mechanism to post-transcriptionally regulate gene expression. Twit Text FOAVip mRNA modifications: Dynamic regulators of gene expression ????RNA Biol http://www.kidney.de/pget.php?&tw=1&pmid=27351916 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27351916 #FOAvip English Wikipedia <ref>{{Cite pmid|27351916}}</ref> mRNA modifications: Dynamic regulators of gene expression? #MMPMID27351916 Hoernes TP; Hüttenhofer A; Erlacher MD RNA Biol 2016[Sep]; 13 (9): 760-5 PMID27351916show ga The expression of a gene is a tightly regulated process and is exerted by a myriad of different mechanisms. Recently, RNA modifications located in coding sequences of mRNAs, have been identified as potential regulators of gene expression. N6-methyladenosine (m6A), 5-methylcytosine (m5C), pseudouridine (?) and N1-methyladenosine (m1A) have been found within open reading frames of mRNAs. The presence of these mRNA modifications has been implicated to modulate the fate of an mRNA, ranging from maturation to its translation and even degradation. However, many aspects concerning the biological functions of mRNA modifications remain elusive. Recently, systematic in vitro studies allowed a first glimpse of the direct interplay of mRNA modifications and the efficiency and fidelity of ribosomal translation. It thereby became evident that the effects of mRNA modifications were, astonishingly versatile, depending on the type, position or sequence context. The incorporation of a single modification could either prematurely terminate protein synthesis, reduce the peptide yield or alter the amino acid sequence identity. These results implicate that mRNA modifications are a powerful mechanism to post-transcriptionally regulate gene expression. ämRNA modifications: Dynamic regulators of gene expression?(epmc).pdf DeepDyve Pubget Overpricing