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10.1080/15476286.2016.1197484 http://scihub22266oqcxt.onion/10.1080/15476286.2016.1197484 C5013987!5013987 !27284727     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27284727 &cmd=llinks): Failed to open stream: HTTP request failed! 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RPTOR, a novel target of miR-155, elicits a fibrotic phenotype of cystic fibrosis lung epithelium by upregulating CTGF |pdf=|usr=}}{{27284727 }} gab.com Text RPTOR, a novel target of miR-155, elicits a fibrotic phenotype of cystic fibrosis lung epithelium by upregulating CTGF JO: RNA Biol http://www.kidney.de/pget.php?&tw=1&pmid=27284727 #FOAvip Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, the most frequent of which is F508del-CFTR. CF is characterized by excessive secretion of pro-inflammatory mediators into the airway lumen, inducing a highly inflammatory cellular phenotype. This process triggers fibrosis, causing airway destruction and leading to high morbidity and mortality. We previously reported that miR-155 is upregulated in CF lung epithelial cells, but the molecular mechanisms by which miR-155 affects the disease phenotype is not understood. Here we report that RPTOR (regulatory associated protein of mTOR, complex 1) is a novel target of miR-155 in CF lung epithelial cells. The suppression of RPTOR expression and subsequent activation of TGF-? signaling resulted in the induction of fibrosis by elevating connective tissue growth factor (CTGF) abundance in CF lung epithelial cells. Thus, we propose that miR-155 might regulate fibrosis of CF lungs through the increased CTGF expression, highlighting its potential value in CF therapy. Twit Text FOAVip RPTOR, a novel target of miR-155, elicits a fibrotic phenotype of cystic fibrosis lung epithelium by upregulating CTGF ????RNA Biol http://www.kidney.de/pget.php?&tw=1&pmid=27284727 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27284727 #FOAvip English Wikipedia <ref>{{Cite pmid|27284727 }}</ref> RPTOR, a novel target of miR-155, elicits a fibrotic phenotype of cystic fibrosis lung epithelium by upregulating CTGF #MMPMID27284727 Tsuchiya M ; Kalurupalle S ; Kumar P ; Ghoshal S ; Zhang Y ; Lehrmann E ; Becker KG ; Gorospe M ; Biswas R RNA Biol 2016[Sep]; 13 (9 ): 837-47 PMID27284727 show ga Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, the most frequent of which is F508del-CFTR. CF is characterized by excessive secretion of pro-inflammatory mediators into the airway lumen, inducing a highly inflammatory cellular phenotype. This process triggers fibrosis, causing airway destruction and leading to high morbidity and mortality. We previously reported that miR-155 is upregulated in CF lung epithelial cells, but the molecular mechanisms by which miR-155 affects the disease phenotype is not understood. Here we report that RPTOR (regulatory associated protein of mTOR, complex 1) is a novel target of miR-155 in CF lung epithelial cells. The suppression of RPTOR expression and subsequent activation of TGF-? signaling resulted in the induction of fibrosis by elevating connective tissue growth factor (CTGF) abundance in CF lung epithelial cells. Thus, we propose that miR-155 might regulate fibrosis of CF lungs through the increased CTGF expression, highlighting its potential value in CF therapy. |*Gene Expression Regulation [MESH] |3' Untranslated Regions [MESH] |Adaptor Proteins, Signal Transducing/*genetics [MESH] |Cell Line [MESH] |Connective Tissue Growth Factor/*genetics [MESH] |Cystic Fibrosis/*genetics/metabolism/pathology [MESH] |Humans [MESH] |Lung/*metabolism/pathology [MESH] |MicroRNAs/*genetics [MESH] |Models, Biological [MESH] |Phenotype [MESH] |RNA Interference [MESH] |RNA, Messenger/genetics [MESH] |Regulatory-Associated Protein of mTOR [MESH] |Reproducibility of Results [MESH] |Respiratory Mucosa/*metabolism/pathology [MESH]RPTOR, a novel target of miR-155, elicits a fibrotic phenotype of cyst(epmc).pdf DeepDyve Pubget Overpricing