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10.1016/j.matbio.2015.06.003 http://scihub22266oqcxt.onion/10.1016/j.matbio.2015.06.003 C5013529!5013529!26163349     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Matrix+Biol 2016 ; 49 (ä): 10-24 Nephropedia Template TP {{tp|p=26163349|t=2016. The Extracellular Matrix: Tools and Insights for the ?Omics? Era |pdf=|usr=}}{{26163349}} gab.com Text The Extracellular Matrix: Tools and Insights for the Omics Era JO: Matrix Biol http://www.kidney.de/pget.php?&tw=1&pmid=26163349 #FOAvip The extracellular matrix (ECM) is a fundamental component of multicellular organisms that provides mechanical and chemical cues that orchestrate cellular and tissue organization and functions. Degradation, hyperproduction or alteration of the composition of the ECM cause or accompany numerous pathologies. Thus, a better characterization of ECM composition, metabolism, and biology can lead to the identification of novel prognostic and diagnostic markers and therapeutic opportunities. The development over the last few years of high-throughput (?omics?) approaches has considerably accelerated the pace of discovery in life sciences. In this review, we describe new bioinformatic tools and experimental strategies for ECM research, and illustrate how these tools and approaches can be exploited to provide novel insights in our understanding of ECM biology. We also introduce a web platform ?the matrisome project? and the database MatrisomeDB that compiles in silico and in vivo data on the matrisome, defined as the ensemble of genes encoding ECM and ECM-associated proteins. Finally, we present a first draft of an ECM atlas built by compiling proteomics data on the ECM composition of 14 different tissues and tumor types. Twit Text FOAVip The Extracellular Matrix: Tools and Insights for the Omics Era ????Matrix Biol http://www.kidney.de/pget.php?&tw=1&pmid=26163349 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26163349 #FOAvip English Wikipedia <ref>{{Cite pmid|26163349}}</ref> The Extracellular Matrix: Tools and Insights for the ?Omics? Era #MMPMID26163349 Naba A; Clauser KR; Ding H; Whittaker CA; Carr SA; Hynes RO Matrix Biol 2016[Jan]; 49 (ä): 10-24 PMID26163349show ga The extracellular matrix (ECM) is a fundamental component of multicellular organisms that provides mechanical and chemical cues that orchestrate cellular and tissue organization and functions. Degradation, hyperproduction or alteration of the composition of the ECM cause or accompany numerous pathologies. Thus, a better characterization of ECM composition, metabolism, and biology can lead to the identification of novel prognostic and diagnostic markers and therapeutic opportunities. The development over the last few years of high-throughput (?omics?) approaches has considerably accelerated the pace of discovery in life sciences. In this review, we describe new bioinformatic tools and experimental strategies for ECM research, and illustrate how these tools and approaches can be exploited to provide novel insights in our understanding of ECM biology. We also introduce a web platform ?the matrisome project? and the database MatrisomeDB that compiles in silico and in vivo data on the matrisome, defined as the ensemble of genes encoding ECM and ECM-associated proteins. Finally, we present a first draft of an ECM atlas built by compiling proteomics data on the ECM composition of 14 different tissues and tumor types. äThe Extracellular Matrix: Tools and Insights for the ?Omics? Era (epmc).pdf DeepDyve Pubget Overpricing