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10.1038/srep32610 http://scihub22266oqcxt.onion/10.1038/srep32610 C5013493!5013493 !27600466     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27600466 &cmd=llinks): Failed to open stream: HTTP request failed! 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Wnt4 is a novel biomarker for the early detection of kidney tubular injury after ischemia/reperfusion injury |pdf=|usr=}}{{27600466 }} gab.com Text Wnt4 is a novel biomarker for the early detection of kidney tubular injury after ischemia/reperfusion injury JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27600466 #FOAvip Earlier intervention after acute kidney injury would promote better outcomes. Our previous study found that Wnt proteins are promptly upregulated after ischemic kidney injury. Thus, we assessed whether Wnt4 could be an early and sensitive biomarker of tubular injury. We subjected mice to bilateral ischemia/reperfusion injury (IRI). Kidney and urinary Wnt4 expression showed an early increase at 3?hours and increased further at 24?hours post-IRI and was closely correlated with histopathological alterations. Serum creatinine slightly increased at 6?hours, indicating that it was less sensitive than Wnt4 expression. These data were further confirmed by clinical study. Both kidney and urinary Wnt4 expression were significantly increased in patients diagnosed with biopsy-proven minimal change disease (MCD) with tubular injury, all of whom nevertheless had normal estimated glomerular filtration rate (eGFR) and serum creatinine. The increased Wnt4 expression also strongly correlated with histopathological alterations in these MCD patients. In conclusion, this is the first demonstration that increases in both kidney and urinary Wnt4 expression can be detected more sensitively and earlier than serum creatinine after kidney injury. In particular, urinary Wnt4 could be a potential noninvasive biomarker for the early detection of tubular injury. Twit Text FOAVip Wnt4 is a novel biomarker for the early detection of kidney tubular injury after ischemia/reperfusion injury ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27600466 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27600466 #FOAvip English Wikipedia <ref>{{Cite pmid|27600466 }}</ref> Wnt4 is a novel biomarker for the early detection of kidney tubular injury after ischemia/reperfusion injury #MMPMID27600466 Zhao SL ; Wei SY ; Wang YX ; Diao TT ; Li JS ; He YX ; Yu J ; Jiang XY ; Cao Y ; Mao XY ; Wei QJ ; Wang Y ; Li B Sci Rep 2016[Sep]; 6 (ä): 32610 PMID27600466 show ga Earlier intervention after acute kidney injury would promote better outcomes. Our previous study found that Wnt proteins are promptly upregulated after ischemic kidney injury. Thus, we assessed whether Wnt4 could be an early and sensitive biomarker of tubular injury. We subjected mice to bilateral ischemia/reperfusion injury (IRI). Kidney and urinary Wnt4 expression showed an early increase at 3?hours and increased further at 24?hours post-IRI and was closely correlated with histopathological alterations. Serum creatinine slightly increased at 6?hours, indicating that it was less sensitive than Wnt4 expression. These data were further confirmed by clinical study. Both kidney and urinary Wnt4 expression were significantly increased in patients diagnosed with biopsy-proven minimal change disease (MCD) with tubular injury, all of whom nevertheless had normal estimated glomerular filtration rate (eGFR) and serum creatinine. The increased Wnt4 expression also strongly correlated with histopathological alterations in these MCD patients. In conclusion, this is the first demonstration that increases in both kidney and urinary Wnt4 expression can be detected more sensitively and earlier than serum creatinine after kidney injury. In particular, urinary Wnt4 could be a potential noninvasive biomarker for the early detection of tubular injury. |Acute Kidney Injury/metabolism/pathology [MESH] |Adult [MESH] |Animals [MESH] |Biomarkers/blood/metabolism [MESH] |Creatinine/blood [MESH] |Female [MESH] |Fluorescent Antibody Technique [MESH] |Glomerular Filtration Rate [MESH] |Hepatitis A Virus Cellular Receptor 1/metabolism [MESH] |Humans [MESH] |In Situ Nick-End Labeling [MESH] |Ki-67 Antigen/metabolism [MESH] |Kidney Tubules/*injuries/metabolism/*pathology/physiopathology [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Middle Aged [MESH] |Nephrosis, Lipoid/metabolism/pathology [MESH] |Reperfusion Injury/blood/*metabolism/*pathology/physiopathology [MESH] |Up-Regulation [MESH]Wnt4 is a novel biomarker for the early detection of kidney tubular in(epmc).pdf DeepDyve Pubget Overpricing