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2016 ; 2016
(ä): 3572705
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Cancer Feature Selection and Classification Using a Binary Quantum-Behaved
Particle Swarm Optimization and Support Vector Machine
#MMPMID27642363
Xi M
; Sun J
; Liu L
; Fan F
; Wu X
Comput Math Methods Med
2016[]; 2016
(ä): 3572705
PMID27642363
show ga
This paper focuses on the feature gene selection for cancer classification, which
employs an optimization algorithm to select a subset of the genes. We propose a
binary quantum-behaved particle swarm optimization (BQPSO) for cancer feature
gene selection, coupling support vector machine (SVM) for cancer classification.
First, the proposed BQPSO algorithm is described, which is a discretized version
of original QPSO for binary 0-1 optimization problems. Then, we present the
principle and procedure for cancer feature gene selection and cancer
classification based on BQPSO and SVM with leave-one-out cross validation
(LOOCV). Finally, the BQPSO coupling SVM (BQPSO/SVM), binary PSO coupling SVM
(BPSO/SVM), and genetic algorithm coupling SVM (GA/SVM) are tested for feature
gene selection and cancer classification on five microarray data sets, namely,
Leukemia, Prostate, Colon, Lung, and Lymphoma. The experimental results show that
BQPSO/SVM has significant advantages in accuracy, robustness, and the number of
feature genes selected compared with the other two algorithms.