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10.1155/2016/3572705

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suck abstract from ncbi


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pmid27642363
      Comput+Math+Methods+Med 2016 ; 2016 (ä): 3572705
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  • Cancer Feature Selection and Classification Using a Binary Quantum-Behaved Particle Swarm Optimization and Support Vector Machine #MMPMID27642363
  • Xi M ; Sun J ; Liu L ; Fan F ; Wu X
  • Comput Math Methods Med 2016[]; 2016 (ä): 3572705 PMID27642363 show ga
  • This paper focuses on the feature gene selection for cancer classification, which employs an optimization algorithm to select a subset of the genes. We propose a binary quantum-behaved particle swarm optimization (BQPSO) for cancer feature gene selection, coupling support vector machine (SVM) for cancer classification. First, the proposed BQPSO algorithm is described, which is a discretized version of original QPSO for binary 0-1 optimization problems. Then, we present the principle and procedure for cancer feature gene selection and cancer classification based on BQPSO and SVM with leave-one-out cross validation (LOOCV). Finally, the BQPSO coupling SVM (BQPSO/SVM), binary PSO coupling SVM (BPSO/SVM), and genetic algorithm coupling SVM (GA/SVM) are tested for feature gene selection and cancer classification on five microarray data sets, namely, Leukemia, Prostate, Colon, Lung, and Lymphoma. The experimental results show that BQPSO/SVM has significant advantages in accuracy, robustness, and the number of feature genes selected compared with the other two algorithms.
  • |Algorithms [MESH]
  • |Computational Biology/*methods [MESH]
  • |Humans [MESH]
  • |Models, Statistical [MESH]
  • |Neoplasms/*diagnosis/*physiopathology [MESH]
  • |Oligonucleotide Array Sequence Analysis [MESH]
  • |Quantum Theory [MESH]
  • |Reproducibility of Results [MESH]


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