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2016 ; 2016
(ä): 7510323
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English Wikipedia
Postpartum Granulomatous Hypophysitis: A Case Study, Review of the Literature,
and Discussion of Pathogenesis
#MMPMID27642532
Joneja U
; Hooper DC
; Evans JJ
; Curtis MT
Case Rep Pathol
2016[]; 2016
(ä): 7510323
PMID27642532
show ga
Hypophysitis is a rare inflammatory condition of the pituitary gland that has
three main histologic subtypes: lymphocytic hypophysitis (LH), granulomatous
hypophysitis (GH), and xanthomatous hypophysitis (XH). Among these, LH is the
most common and is strongly associated with the postpartum state, while XH is the
least common. Many hypophysitis cases have been reported in the literature but
only a few cases of postpartum GH have been discussed. Here, we describe a case
of GH in a 24-year-old female presenting eleven days postpartum. We also review
the current literature on postpartum GH and discuss the possible alterations in
the immune environment during and after pregnancy that could explain this
phenomenon. With more cases of GH being reported, the commonalities of female
predominance, postpartum time of presentation, and occasional spontaneous
resolution between LH and GH lend support to the theory that these two diseases
likely represent spectrums of a single immunologic disorder.