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10.1155/2016/1579490

http://scihub22266oqcxt.onion/10.1155/2016/1579490
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C5013215!5013215!27642589
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suck abstract from ncbi


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pmid27642589      Biomed+Res+Int 2016 ; 2016 (ä): ä
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  • Circular RNA-ITCH Suppresses Lung Cancer Proliferation via Inhibiting the Wnt/?-Catenin Pathway #MMPMID27642589
  • Wan L; Zhang L; Fan K; Cheng ZX; Sun QC; Wang JJ
  • Biomed Res Int 2016[]; 2016 (ä): ä PMID27642589show ga
  • As a special form of noncoding RNAs, circular RNAs (circRNAs) played important roles in regulating cancer progression mainly by functioning as miRNA sponge. While the function of circular RNA-ITCH (cir-ITCH) in lung cancer is still less reported, in this study, we firstly detected the expression of cir-ITCH in tumor tissues and paired adjacent noncancer tissues of 78 patients with lung cancer using a TaqMan-based quantitative real-time PCR (qRT-PCR). The results showed that the expression of cir-ITCH was significantly decreased in lung cancer tissues. In cellular studies, cir-ITCH was also enhanced in different lung cancer cell lines, A549 and NIC-H460. Ectopic expression of cir-ITCH markedly elevated its parental cancer-suppressive gene, ITCH, expression and inhibited proliferation of lung cancer cells. Molecular analysis further revealed that cir-ITCH acted as sponge of oncogenic miR-7 and miR-214 to enhance ITCH expression and thus suppressed the activation of Wnt/?-catenin signaling. Altogether, our results suggested that cir-ITCH may play an inhibitory role in lung cancer progression by enhancing its parental gene, ITCH, expression.
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