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10.1136/annrheumdis-2015-207923 http://scihub22266oqcxt.onion/10.1136/annrheumdis-2015-207923 C5013081!5013081!26470720     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+Rheum+Dis 2016 ; 75 (9): 1714-21 Nephropedia Template TP {{tp|p=26470720|t=2016. Halofuginone attenuates osteoarthritis by inhibition of TGF-? activity and H-type vessel formation in subchondral bone |pdf=|usr=}}{{26470720}} gab.com Text Halofuginone attenuates osteoarthritis by inhibition of TGF- activity and H-type vessel formation in subchondral bone JO: Ann Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=26470720 #FOAvip Objectives: Examine whether osteoarthritis (OA) progression can be delayed by halofuginone in anterior cruciate ligament transection (ACLT) rodent models. Methods: 3-month-old male C57BL/6J (wild type; WT) mice and Lewis rats were randomised to sham-operated, ACLT-operated, treated with vehicle, or ACLT-operated, treated with halofuginone. Articular cartilage degeneration was graded using the Osteoarthritis Research Society International (OARSI)-modified Mankin criteria. Immunostaining, flow cytometry, RT-PCR and western blot analyses were conducted to detect relative protein and RNA expression. Bone micro CT (?CT) and CT-based microangiography were quantitated to detect alterations of microarchitecture and vasculature in tibial subchondral bone. Results: Halofuginone attenuated articular cartilage degeneration and subchondral bone deterioration, resulting in substantially lower OARSI scores. Specifically, we found that proteoglycan loss and calcification of articular cartilage were significantly decreased in halofuginone-treated ACLT rodents compared with vehicle-treated ACLT controls. Halofuginone reduced collagen X (Col X), matrix metalloproteinase-13 and A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS 5) and increased lubricin, collagen II and aggrecan. In parallel, halofuginone-attenuated uncoupled subchondral bone remodelling as defined by reduced subchondral bone tissue volume, lower trabecular pattern factor (Tb.pf) and increased thickness of subchondral bone plate compared with vehicle-treated ACLT controls. We found that halofuginone exerted protective effects in part by suppressing Th17-induced osteoclastic bone resorption, inhibiting Smad2/3-dependent TGF-? signalling to restore coupled bone remodelling and attenuating excessive angiogenesis in subchondral bone. Conclusions: Halofuginone attenuates OA progression by inhibition of subchondral bone TGF-? activity and aberrant angiogenesis as a potential preventive therapy for OA. Twit Text FOAVip Halofuginone attenuates osteoarthritis by inhibition of TGF- activity and H-type vessel formation in subchondral bone ????Ann Rheum Dis http://www.kidney.de/pget.php?&tw=1&pmid=26470720 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26470720 #FOAvip English Wikipedia <ref>{{Cite pmid|26470720}}</ref> Halofuginone attenuates osteoarthritis by inhibition of TGF-? activity and H-type vessel formation in subchondral bone #MMPMID26470720 Cui Z; Crane J; Xie H; Jin X; Zhen G; Li C; Xie L; Wang L; Bian Q; Qiu T; Wan M; Xie M; Ding S; Yu B; Cao X Ann Rheum Dis 2016[Sep]; 75 (9): 1714-21 PMID26470720show ga Objectives: Examine whether osteoarthritis (OA) progression can be delayed by halofuginone in anterior cruciate ligament transection (ACLT) rodent models. Methods: 3-month-old male C57BL/6J (wild type; WT) mice and Lewis rats were randomised to sham-operated, ACLT-operated, treated with vehicle, or ACLT-operated, treated with halofuginone. Articular cartilage degeneration was graded using the Osteoarthritis Research Society International (OARSI)-modified Mankin criteria. Immunostaining, flow cytometry, RT-PCR and western blot analyses were conducted to detect relative protein and RNA expression. Bone micro CT (?CT) and CT-based microangiography were quantitated to detect alterations of microarchitecture and vasculature in tibial subchondral bone. Results: Halofuginone attenuated articular cartilage degeneration and subchondral bone deterioration, resulting in substantially lower OARSI scores. Specifically, we found that proteoglycan loss and calcification of articular cartilage were significantly decreased in halofuginone-treated ACLT rodents compared with vehicle-treated ACLT controls. Halofuginone reduced collagen X (Col X), matrix metalloproteinase-13 and A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS 5) and increased lubricin, collagen II and aggrecan. In parallel, halofuginone-attenuated uncoupled subchondral bone remodelling as defined by reduced subchondral bone tissue volume, lower trabecular pattern factor (Tb.pf) and increased thickness of subchondral bone plate compared with vehicle-treated ACLT controls. We found that halofuginone exerted protective effects in part by suppressing Th17-induced osteoclastic bone resorption, inhibiting Smad2/3-dependent TGF-? signalling to restore coupled bone remodelling and attenuating excessive angiogenesis in subchondral bone. Conclusions: Halofuginone attenuates OA progression by inhibition of subchondral bone TGF-? activity and aberrant angiogenesis as a potential preventive therapy for OA. äHalofuginone attenuates osteoarthritis by inhibition of TGF-? activity(epmc).pdf DeepDyve Pubget Overpricing