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10.3389/fcell.2016.00096 http://scihub22266oqcxt.onion/10.3389/fcell.2016.00096 C5013040!5013040!27656643     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Cell+Dev+Biol 2016 ; 4 (ä): ä Nephropedia Template TP {{tp|p=27656643|t=2016. The Immunomodulatory Functions of Diacylglycerol Kinase ? |pdf=|usr=}}{{27656643}} gab.com Text The Immunomodulatory Functions of Diacylglycerol Kinase JO: Front Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=27656643 #FOAvip The generation of diacylglycerol (DAG) is critical for promoting immune cell activation, regulation, and function. Diacylglycerol kinase ? (DGK?) serves as an important negative regulator of DAG by enzymatically converting DAG into phosphatidic acid (PA) to shut down DAG-mediated signaling. Consequently, the loss of DGK? increases DAG levels and the duration of DAG-mediated signaling. However, while the enhancement of DAG signaling is thought to augment immune cell function, the loss of DGK? can result in both immunoactivation and immunomodulation depending on the cell type and function. In this review, we discuss how different immune cell functions can be selectively modulated by DGK?. Furthermore, we consider how targeting DGK? can be potentially beneficial for the resolution of human diseases by either promoting immune responses important for protection against infection or cancer or dampening immune responses in immunopathologic conditions such as allergy and septic shock. Twit Text FOAVip The Immunomodulatory Functions of Diacylglycerol Kinase ????Front Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=27656643 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27656643 #FOAvip English Wikipedia <ref>{{Cite pmid|27656643}}</ref> The Immunomodulatory Functions of Diacylglycerol Kinase ? #MMPMID27656643 Singh BK; Kambayashi T Front Cell Dev Biol 2016[]; 4 (ä): ä PMID27656643show ga The generation of diacylglycerol (DAG) is critical for promoting immune cell activation, regulation, and function. Diacylglycerol kinase ? (DGK?) serves as an important negative regulator of DAG by enzymatically converting DAG into phosphatidic acid (PA) to shut down DAG-mediated signaling. Consequently, the loss of DGK? increases DAG levels and the duration of DAG-mediated signaling. However, while the enhancement of DAG signaling is thought to augment immune cell function, the loss of DGK? can result in both immunoactivation and immunomodulation depending on the cell type and function. In this review, we discuss how different immune cell functions can be selectively modulated by DGK?. Furthermore, we consider how targeting DGK? can be potentially beneficial for the resolution of human diseases by either promoting immune responses important for protection against infection or cancer or dampening immune responses in immunopathologic conditions such as allergy and septic shock. äThe Immunomodulatory Functions of Diacylglycerol Kinase ? (epmc).pdf DeepDyve Pubget Overpricing