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10.2147/OTT.S111794 http://scihub22266oqcxt.onion/10.2147/OTT.S111794 C5012848!5012848!27621655     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Onco+Targets+Ther 2016 ; 9 (ä): 5417-25 Nephropedia Template TP {{tp|p=27621655|t=2016. Long noncoding RNA SPRY4-IT1 promotes malignant development of colorectal cancer by targeting epithelial?mesenchymal transition |pdf=|usr=}}{{27621655}} gab.com Text Long noncoding RNA SPRY4-IT1 promotes malignant development of colorectal cancer by targeting epithelial mesenchymal transition JO: Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=27621655 #FOAvip The clinical significance and biological functions of long noncoding RNA SPRY4 intronic transcript 1 (SPRY4-IT1) in colorectal cancer (CRC) remain largely unclear. Herein, we are the first to report that the SPRY4-IT1 was significantly upregulated in CRC tissues, serum, and cells. Higher SPRY4-IT1 expression was markedly associated with advanced Tumor Node Metastasis (TNM) stage in a cohort of 84 CRC patients. Multivariate analyses indicated that SPRY4-IT1 expression could be useful as an independent predictor for overall survival. Further in vitro experiments revealed that knockdown of SPRY4-IT1 inhibited the proliferation, migration, and invasion of CRC cells and induced cell cycle arrestment. Moreover, we confirmed that the expression of epithelial?mesenchymal transition-related genes was modulated through alteration of SPRY4-IT1 expression. These results suggest that SPRY4-IT1, as an oncogenic regulator, may serve as a candidate prognostic marker and potential target for CRC therapies. Twit Text FOAVip Long noncoding RNA SPRY4-IT1 promotes malignant development of colorectal cancer by targeting epithelial mesenchymal transition ????Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=27621655 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27621655 #FOAvip English Wikipedia <ref>{{Cite pmid|27621655}}</ref> Long noncoding RNA SPRY4-IT1 promotes malignant development of colorectal cancer by targeting epithelial?mesenchymal transition #MMPMID27621655 Cao D; Ding Q; Yu W; Gao M; Wang Y Onco Targets Ther 2016[]; 9 (ä): 5417-25 PMID27621655show ga The clinical significance and biological functions of long noncoding RNA SPRY4 intronic transcript 1 (SPRY4-IT1) in colorectal cancer (CRC) remain largely unclear. Herein, we are the first to report that the SPRY4-IT1 was significantly upregulated in CRC tissues, serum, and cells. Higher SPRY4-IT1 expression was markedly associated with advanced Tumor Node Metastasis (TNM) stage in a cohort of 84 CRC patients. Multivariate analyses indicated that SPRY4-IT1 expression could be useful as an independent predictor for overall survival. Further in vitro experiments revealed that knockdown of SPRY4-IT1 inhibited the proliferation, migration, and invasion of CRC cells and induced cell cycle arrestment. Moreover, we confirmed that the expression of epithelial?mesenchymal transition-related genes was modulated through alteration of SPRY4-IT1 expression. These results suggest that SPRY4-IT1, as an oncogenic regulator, may serve as a candidate prognostic marker and potential target for CRC therapies. äLong noncoding RNA SPRY4-IT1 promotes malignant development of colorec(epmc).pdf DeepDyve Pubget Overpricing