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2016 ; 11
(9
): 1681-1691
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Bridging the Divide: An Onco-Nephrologic Approach to the Monoclonal Gammopathies
of Renal Significance
#MMPMID27416775
Hogan JJ
; Weiss BM
Clin J Am Soc Nephrol
2016[Sep]; 11
(9
): 1681-1691
PMID27416775
show ga
The monoclonal gammopathies of renal significance (MGRS) are a group of disorders
characterized by monoclonal Ig deposition in the kidney, but are not associated
with systemic lymphoma or overt multiple myeloma. The prevailing hypothesis is
that the pathogenic paraproteins in MGRS are produced by underlying B cell or
plasma cell clones. However, in the MGRS literature, the yield of detecting a
clone has been variable, and progression to ESRD is common. Here, we present an
"onco-nephrologic" approach to the MGRS disorders by highlighting recent advances
in lymphoma and multiple myeloma that can be used in the evaluation and
management of these patients.
|Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
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