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10.1007/s13277-014-2846-4 http://scihub22266oqcxt.onion/10.1007/s13277-014-2846-4 C5012430!5012430 !25416442     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25416442 &cmd=llinks): Failed to open stream: HTTP request failed! 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Epigenetic regulation of human hedgehog interacting protein in glioma cell lines and primary tumor samples |pdf=|usr=}}{{25416442 }} gab.com Text Epigenetic regulation of human hedgehog interacting protein in glioma cell lines and primary tumor samples JO: Tumour Biol http://www.kidney.de/pget.php?&tw=1&pmid=25416442 #FOAvip Glioma constitutes one of the most common groups of brain tumors, and its prognosis is influenced by different genetic and epigenetic modulations. In this study, we demonstrated low or no expression of hedgehog interacting protein (HHIP) in most of the cell lines and primary glioma tumor samples. We further proceeded to promoter methylation study of this gene in the same cell lines and primary tumor samples and found 87 % (7/8) HHIP methylation in glioblastoma cell lines and 75 % (33/44) in primary tumor samples. These methylation pattern correlates with low or unexpressed HHIP in both cell lines and primary tumor samples. Our results suggest the possibility of epigenetic regulation of this gene in glioma, similarly to medulloblastoma, gastric, hepatic, and pancreatic cancers. Also, HHIP might be a diagnostic or prognostic marker in glioma and help to the detection of these tumors in early stages of disease. Twit Text FOAVip Epigenetic regulation of human hedgehog interacting protein in glioma cell lines and primary tumor samples ????Tumour Biol http://www.kidney.de/pget.php?&tw=1&pmid=25416442 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25416442 #FOAvip English Wikipedia <ref>{{Cite pmid|25416442 }}</ref> Epigenetic regulation of human hedgehog interacting protein in glioma cell lines and primary tumor samples #MMPMID25416442 Shahi MH ; Zazpe I ; Afzal M ; Sinha S ; Rebhun RB ; Meléndez B ; Rey JA ; Castresana JS Tumour Biol 2015[Apr]; 36 (4 ): 2383-91 PMID25416442 show ga Glioma constitutes one of the most common groups of brain tumors, and its prognosis is influenced by different genetic and epigenetic modulations. In this study, we demonstrated low or no expression of hedgehog interacting protein (HHIP) in most of the cell lines and primary glioma tumor samples. We further proceeded to promoter methylation study of this gene in the same cell lines and primary tumor samples and found 87 % (7/8) HHIP methylation in glioblastoma cell lines and 75 % (33/44) in primary tumor samples. These methylation pattern correlates with low or unexpressed HHIP in both cell lines and primary tumor samples. Our results suggest the possibility of epigenetic regulation of this gene in glioma, similarly to medulloblastoma, gastric, hepatic, and pancreatic cancers. Also, HHIP might be a diagnostic or prognostic marker in glioma and help to the detection of these tumors in early stages of disease. |Adult [MESH] |Brain Neoplasms/*genetics/pathology [MESH] |Carrier Proteins/*biosynthesis/genetics [MESH] |Cell Line, Tumor [MESH] |DNA Methylation/*genetics [MESH] |Epigenesis, Genetic [MESH] |Gene Expression Regulation, Neoplastic/genetics [MESH] |Glioma/*genetics/pathology [MESH] |Humans [MESH] |Membrane Glycoproteins/*biosynthesis/genetics [MESH] |Promoter Regions, Genetic [MESH] |Transcription Factors/biosynthesis [MESH]Epigenetic regulation of human hedgehog interacting protein in glioma (epmc).pdf DeepDyve Pubget Overpricing