Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/s13340-014-0177-8 http://scihub22266oqcxt.onion/10.1007/s13340-014-0177-8 C5012410!5012410!27656338     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetol+Int 2014 ; 5 (4): 212-8 Nephropedia Template TP {{tp|p=27656338|t=2014. Salicylic acid: old and new implications for the treatment of type 2 diabetes?|pdf=|usr=}}{{27656338}} gab.com Text Salicylic acid: old and new implications for the treatment of type 2 diabetes JO: Diabetol Int http://www.kidney.de/pget.php?&tw=1&pmid=27656338 #FOAvip Efficacy of salicylic acid as a treatment for diabetes was first established well over a century ago. Antihyperglycaemic effects are thought to include improved peripheral insulin sensitivity and suppression of hepatic glucose production. For most of this period, the molecular mechanisms underlying these effects have been poorly understood and these are still a focus of considerable research, which is reviewed here. Antihyperglycaemic effects are observed only at much higher concentrations than analgesic, antipyretic and antithrombotic properties, suggesting that different targets underlie the antidiabetic aspects of salicylate pharmacology. In the 1950s, antihyperglycaemic responses were linked to mitochondrial uncoupling effects of the drug. Then at the beginning of this century, antihyperglycaemic effects were linked to anti-inflammatory effects of the drug on NF-?B signalling. More recently, new work suggests that direct activation of AMPK may contribute to antihyperglycaemic/antihyperlipidemic actions of salicylates. Better understanding of the mechanism of salicylate?s anthyperglycaemic effects may ultimately accelerate the development of new drugs for human use. Twit Text FOAVip Salicylic acid: old and new implications for the treatment of type 2 diabetes ????Diabetol Int http://www.kidney.de/pget.php?&tw=1&pmid=27656338 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27656338 #FOAvip English Wikipedia <ref>{{Cite pmid|27656338}}</ref> Salicylic acid: old and new implications for the treatment of type 2 diabetes? #MMPMID27656338 Rena G; Sakamoto K Diabetol Int 2014[]; 5 (4): 212-8 PMID27656338show ga Efficacy of salicylic acid as a treatment for diabetes was first established well over a century ago. Antihyperglycaemic effects are thought to include improved peripheral insulin sensitivity and suppression of hepatic glucose production. For most of this period, the molecular mechanisms underlying these effects have been poorly understood and these are still a focus of considerable research, which is reviewed here. Antihyperglycaemic effects are observed only at much higher concentrations than analgesic, antipyretic and antithrombotic properties, suggesting that different targets underlie the antidiabetic aspects of salicylate pharmacology. In the 1950s, antihyperglycaemic responses were linked to mitochondrial uncoupling effects of the drug. Then at the beginning of this century, antihyperglycaemic effects were linked to anti-inflammatory effects of the drug on NF-?B signalling. More recently, new work suggests that direct activation of AMPK may contribute to antihyperglycaemic/antihyperlipidemic actions of salicylates. Better understanding of the mechanism of salicylate?s anthyperglycaemic effects may ultimately accelerate the development of new drugs for human use. äSalicylic acid: old and new implications for the treatment of type 2 d(epmc).pdf DeepDyve Pubget Overpricing