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10.1038/srep32523 http://scihub22266oqcxt.onion/10.1038/srep32523 C5011650!5011650 !27597445     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27597445 &cmd=llinks): Failed to open stream: HTTP request failed! 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Genotypes of cancer stem cells characterized by epithelial-to-mesenchymal transition and proliferation related functions |pdf=|usr=}}{{27597445 }} gab.com Text Genotypes of cancer stem cells characterized by epithelial-to-mesenchymal transition and proliferation related functions JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27597445 #FOAvip Cancer stem cells (CSCs), or cancer cells with stem cell-like properties, generally exhibit drug resistance and have highly potent cancer inducing capabilities. Genome-wide expression data collected at public repositories over the last few years provide excellent material for studies that can lead to insights concerning the molecular and functional characteristics of CSCs. Here, we conducted functional genomic studies of CSC based on fourteen PCA-screened high quality public CSC whole genome gene expression datasets and, as control, four high quality non-stem-like cancer cell and non-cancerous stem cell datasets from the Gene Expression Omnibus database. A total of 6,002 molecular signatures were taken from the Molecular Signatures Database and used to characterize the datasets, which, under two-way hierarchical clustering, formed three genotypes. Type 1, consisting of mainly glia CSCs, had significantly enhanced proliferation, and significantly suppressed epithelial-mesenchymal transition (EMT), related functions. Type 2, mainly breast CSCs, had significantly enhanced EMT, but not proliferation, related functions. Type 3, composed of ovarian, prostate, and colon CSCs, had significantly suppressed proliferation related functions and mixed expressions on EMT related functions. Twit Text FOAVip Genotypes of cancer stem cells characterized by epithelial-to-mesenchymal transition and proliferation related functions ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27597445 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27597445 #FOAvip English Wikipedia <ref>{{Cite pmid|27597445 }}</ref> Genotypes of cancer stem cells characterized by epithelial-to-mesenchymal transition and proliferation related functions #MMPMID27597445 Hsu CL ; Chung FH ; Chen CH ; Hsu TT ; Liu SM ; Chung DS ; Hsu YF ; Chen CL ; Ma N ; Lee HC Sci Rep 2016[Sep]; 6 (ä): 32523 PMID27597445 show ga Cancer stem cells (CSCs), or cancer cells with stem cell-like properties, generally exhibit drug resistance and have highly potent cancer inducing capabilities. Genome-wide expression data collected at public repositories over the last few years provide excellent material for studies that can lead to insights concerning the molecular and functional characteristics of CSCs. Here, we conducted functional genomic studies of CSC based on fourteen PCA-screened high quality public CSC whole genome gene expression datasets and, as control, four high quality non-stem-like cancer cell and non-cancerous stem cell datasets from the Gene Expression Omnibus database. A total of 6,002 molecular signatures were taken from the Molecular Signatures Database and used to characterize the datasets, which, under two-way hierarchical clustering, formed three genotypes. Type 1, consisting of mainly glia CSCs, had significantly enhanced proliferation, and significantly suppressed epithelial-mesenchymal transition (EMT), related functions. Type 2, mainly breast CSCs, had significantly enhanced EMT, but not proliferation, related functions. Type 3, composed of ovarian, prostate, and colon CSCs, had significantly suppressed proliferation related functions and mixed expressions on EMT related functions. |Cell Proliferation [MESH] |Cluster Analysis [MESH] |Databases, Genetic [MESH] |Epithelial-Mesenchymal Transition/*genetics [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Gene Ontology [MESH] |Genotype [MESH] |Humans [MESH] |Neoplastic Stem Cells/*metabolism/*pathology [MESH]Genotypes of cancer stem cells characterized by epithelial-to-mesenchy(epmc).pdf DeepDyve Pubget Overpricing