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10.1155/2016/8128957 http://scihub22266oqcxt.onion/10.1155/2016/8128957 C5011526!5011526 !27642495     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27642495 &cmd=llinks): Failed to open stream: HTTP request failed! 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Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4/COX-2 Pathway in Rats with Hypertension |pdf=|usr=}}{{27642495 }} gab.com Text Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4/COX-2 Pathway in Rats with Hypertension JO: Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=27642495 #FOAvip Aims. We object to elucidate that protective effect of H2S on endothelium is mediated by downregulating BMP4 (bone morphogenetic protein 4)/cyclooxygenase- (COX-) 2 pathway in rats with hypertension. Methods and Results. The hypertensive rat model induced by two-kidney one-clip (2K1C) model was used. Exogenous NaHS administration (56??mol/kg/day, intraperitoneally once a day) reduced mean arterial pressure (MAP) of 2K1C rats from 199.9 ± 3.312?mmHg to 159.4 ± 5.434?mmHg, while NaHS did not affect the blood pressure in the Sham rats and ameliorated endothelium-dependent contractions (EDCs) of renal artery in 2K1C rats. 2K1C reduced CSE level twofold, decreased plasma levels of H2S about 6-fold, increased BMP4, Nox2, and Nox4 levels 2-fold and increased markers of oxidative stress MDA and nitrotyrosine 1.5-fold, upregulated the expression of phosphorylation-p38 MAPK 2-fold, and increased protein levels of COX-2 1.5-fold, which were abolished by NaHS treatment. Conclusions. Our results demonstrate that H2S prevents activation of BMP4/COX-2 pathway in hypertension, which may be involved in the ameliorative effect of H2S on endothelial impairment. These results throw light on endothelial protective effect of H2S and provide new target for prevention and therapy of hypertension. Twit Text FOAVip Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4/COX-2 Pathway in Rats with Hypertension ????Oxid Med Cell Longev http://www.kidney.de/pget.php?&tw=1&pmid=27642495 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27642495 #FOAvip English Wikipedia <ref>{{Cite pmid|27642495 }}</ref> Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating BMP4/COX-2 Pathway in Rats with Hypertension #MMPMID27642495 Xiao L ; Dong JH ; Jin S ; Xue HM ; Guo Q ; Teng X ; Wu YM Oxid Med Cell Longev 2016[]; 2016 (ä): 8128957 PMID27642495 show ga Aims. We object to elucidate that protective effect of H2S on endothelium is mediated by downregulating BMP4 (bone morphogenetic protein 4)/cyclooxygenase- (COX-) 2 pathway in rats with hypertension. Methods and Results. The hypertensive rat model induced by two-kidney one-clip (2K1C) model was used. Exogenous NaHS administration (56??mol/kg/day, intraperitoneally once a day) reduced mean arterial pressure (MAP) of 2K1C rats from 199.9 ± 3.312?mmHg to 159.4 ± 5.434?mmHg, while NaHS did not affect the blood pressure in the Sham rats and ameliorated endothelium-dependent contractions (EDCs) of renal artery in 2K1C rats. 2K1C reduced CSE level twofold, decreased plasma levels of H2S about 6-fold, increased BMP4, Nox2, and Nox4 levels 2-fold and increased markers of oxidative stress MDA and nitrotyrosine 1.5-fold, upregulated the expression of phosphorylation-p38 MAPK 2-fold, and increased protein levels of COX-2 1.5-fold, which were abolished by NaHS treatment. Conclusions. Our results demonstrate that H2S prevents activation of BMP4/COX-2 pathway in hypertension, which may be involved in the ameliorative effect of H2S on endothelial impairment. These results throw light on endothelial protective effect of H2S and provide new target for prevention and therapy of hypertension. |Animals [MESH] |Blood Pressure/drug effects [MESH] |Bone Morphogenetic Protein 4/*metabolism [MESH] |Cyclooxygenase 2/*metabolism [MESH] |Down-Regulation/*drug effects [MESH] |Endothelium, Vascular/drug effects/pathology/*physiopathology [MESH] |Hydrogen Sulfide/administration & dosage/blood/*pharmacology/therapeutic use [MESH] |Hypertension/blood/drug therapy/*physiopathology [MESH] |Male [MESH] |Oxidative Stress/drug effects [MESH] |Phosphorylation/drug effects [MESH] |Rats, Sprague-Dawley [MESH] |Renal Artery/drug effects/pathology/physiopathology [MESH] |Signal Transduction/drug effects [MESH] |Vasoconstriction/drug effects [MESH]Hydrogen Sulfide Improves Endothelial Dysfunction via Downregulating B(epmc).pdf DeepDyve Pubget Overpricing