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10.1016/j.celrep.2016.07.082 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.07.082 C5011426!5011426!27545895     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 16 (9): 2415-27 Nephropedia Template TP {{tp|p=27545895|t=2016. PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development |pdf=|usr=}}{{27545895}} gab.com Text PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27545895 #FOAvip The precise molecular mechanisms that coordinate apoptosis and autophagy in cancer remain to be determined. Here, we provide evidence that the tumor suppressor promyelocytic leukemia protein (PML) controls autophagosome formation at mitochondria-associated membranes (MAMs) and, thus, autophagy induction. Our in vitro and in vivo results demonstrate how PML functions as a repressor of autophagy. PML loss promotes tumor development, providing a growth advantage to tumor cells that use autophagy as a cell survival strategy during stress conditions. These findings demonstrate that autophagy inhibition could be paired with a chemotherapeutic agent to develop anticancer strategies for tumors that present PML downregulation. Twit Text FOAVip PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27545895 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27545895 #FOAvip English Wikipedia <ref>{{Cite pmid|27545895}}</ref> PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development #MMPMID27545895 Missiroli S; Bonora M; Patergnani S; Poletti F; Perrone M; Gafà R; Magri E; Raimondi A; Lanza G; Tacchetti C; Kroemer G; Pandolfi P; Pinton P; Giorgi C Cell Rep 2016[Aug]; 16 (9): 2415-27 PMID27545895show ga The precise molecular mechanisms that coordinate apoptosis and autophagy in cancer remain to be determined. Here, we provide evidence that the tumor suppressor promyelocytic leukemia protein (PML) controls autophagosome formation at mitochondria-associated membranes (MAMs) and, thus, autophagy induction. Our in vitro and in vivo results demonstrate how PML functions as a repressor of autophagy. PML loss promotes tumor development, providing a growth advantage to tumor cells that use autophagy as a cell survival strategy during stress conditions. These findings demonstrate that autophagy inhibition could be paired with a chemotherapeutic agent to develop anticancer strategies for tumors that present PML downregulation. äPML at Mitochondria-Associated Membranes Is Critical for the Repressio(epmc).pdf DeepDyve Pubget Overpricing