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10.1155/2016/5767106 http://scihub22266oqcxt.onion/10.1155/2016/5767106 C5011227!5011227 !27635407     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27635407 &cmd=llinks): Failed to open stream: HTTP request failed! 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Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets? |pdf=|usr=}}{{27635407 }} gab.com Text Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets JO: J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=27635407 #FOAvip Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by B cell hyperactivity leading to the production of autoantibodies, some of which having a deleterious effect. Reducing autoantibody production thus represents a way of controlling lupus pathogenesis, and a better understanding of the molecular and cellular factors involved in the differentiation of B cells into plasma cells could allow identifying new therapeutic targets. Follicular helper T cells (TFH) represent a distinct subset of CD4(+) T cells specialized in providing help to B cells. They are required for the formation of germinal centers and the generation of long-lived serological memory and, as such, are suspected to play a central role in SLE. Recent advances in the field of TFH biology have allowed the identification of important molecular factors involved in TFH differentiation, regulation, and function. Interestingly, some of these TFH-related molecules have been described to be dysregulated in lupus patients. In the present review, we give an overview of the aberrant expression and/or function of such key players in lupus, and we highlight their potential as therapeutic targets. Twit Text FOAVip Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets ????J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=27635407 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27635407 #FOAvip English Wikipedia <ref>{{Cite pmid|27635407 }}</ref> Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets? #MMPMID27635407 Sawaf M ; Dumortier H ; Monneaux F J Immunol Res 2016[]; 2016 (ä): 5767106 PMID27635407 show ga Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by B cell hyperactivity leading to the production of autoantibodies, some of which having a deleterious effect. Reducing autoantibody production thus represents a way of controlling lupus pathogenesis, and a better understanding of the molecular and cellular factors involved in the differentiation of B cells into plasma cells could allow identifying new therapeutic targets. Follicular helper T cells (TFH) represent a distinct subset of CD4(+) T cells specialized in providing help to B cells. They are required for the formation of germinal centers and the generation of long-lived serological memory and, as such, are suspected to play a central role in SLE. Recent advances in the field of TFH biology have allowed the identification of important molecular factors involved in TFH differentiation, regulation, and function. Interestingly, some of these TFH-related molecules have been described to be dysregulated in lupus patients. In the present review, we give an overview of the aberrant expression and/or function of such key players in lupus, and we highlight their potential as therapeutic targets. |Adult [MESH] |Autoantibodies/immunology [MESH] |B-Lymphocytes/immunology [MESH] |Cell Differentiation [MESH] |Germinal Center/*cytology/immunology [MESH] |Humans [MESH] |Lupus Erythematosus, Systemic/immunology/physiopathology/*therapy [MESH] |Molecular Targeted Therapy [MESH] |Plasma Cells/immunology [MESH]Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should (epmc).pdf DeepDyve Pubget Overpricing