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2016 ; 18
(9
): 69
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Renal Afferents
#MMPMID27595156
Frame AA
; Carmichael CY
; Wainford RD
Curr Hypertens Rep
2016[Sep]; 18
(9
): 69
PMID27595156
show ga
PURPOSE OF REVIEW: The etiology of hypertension, a critical public health issue
affecting one in three US adults, involves the integration of the actions of
multiple organ systems, including the renal sympathetic nerves. The renal
sympathetic nerves, which are comprised of both afferent (sensory input) and
efferent (sympathetic outflow) arms, have emerged as a major potential
therapeutic target to treat hypertension and disease states exhibiting excess
renal sympathetic activity. RECENT FINDINGS: This review highlights recent
advances in both clinical and basic science that have provided new insight into
the distribution, function, and reinnervation of the renal sympathetic nerves,
with a focus on the renal afferent nerves, in hypertension and
hypertension-evoked disease states including salt-sensitive hypertension,
obesity-induced hypertension, and chronic kidney disease. Increased understanding
of the differential role of the renal afferent versus efferent nerves in the
pathophysiology of hypertension has the potential to identify novel targets and
refine therapeutic interventions designed to treat hypertension.
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