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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Allergy+Asthma+Immunol+Res 2016 ; 8 (6): 541-4 Nephropedia Template TP
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The Basophil Activation Test Is Safe and Useful for Confirming Drug-Induced Anaphylaxis #MMPMID27582406
Kim SY; Kim JH; Jang YS; Choi JH; Park S; Hwang YI; Jang SH; Jung KS
Allergy Asthma Immunol Res 2016[Nov]; 8 (6): 541-4 PMID27582406show ga
The basophil activation test (BAT) has been suggested as a complementary method for diagnosing drug allergies. The aim of this study was to evaluate the clinical utility of this test in patients with drug-induced anaphylaxis. In total, 19 patients, all of whom had a history of moderate to severe anaphylaxis, were enrolled. None of the causative drugs had available in vitro tests or reliable skin tests; these drugs included, among others, first and second-generation cephalosporins, H2 blockers, and muscle relaxants. The BAT yielded positive results in 57.9% of the cases, which was similar those results of skin prick and intradermal tests (42.1% and 57.9%, respectively). When basophils were double labelled with CD63 and CD203c, both of which are basophil activation markers, the positive rate was increased from 57.9% to 73.7%. Therefore, the results of this study confirm that the BAT is a quick, reliable, and safe diagnostic tool for patients with drug-induced anaphylaxis.