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10.4049/jimmunol.1502383 http://scihub22266oqcxt.onion/10.4049/jimmunol.1502383 C5010937!5010937!27496971     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2016 ; 197 (6): 2465-72 Nephropedia Template TP {{tp|p=27496971|t=2016. The ETS family transcription factors Etv5 and PU 1 function in parallel to promote Th9 cell development |pdf=|usr=}}{{27496971}} gab.com Text The ETS family transcription factors Etv5 and PU 1 function in parallel to promote Th9 cell development JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27496971 #FOAvip The IL-9-secreting Th9 subset of CD4 T helper cells develop in response to an environment containing IL-4 and TGF?, promoting allergic disease, autoimmunity, and resistance to pathogens. We previously identified a requirement for the ETS family transcription factor PU.1 in Th9 development. In this report we demonstrate that the ETS transcription factor ETV5 promotes IL-9 production in Th9 cells by binding and recruiting histone acetyltransferases to the Il9 locus at sites distinct from PU.1. In cells that are deficient in both PU.1 and ETV5 there is lower IL-9 production than in cells lacking either factor alone. In vivo loss of PU.1 and ETV5 in T cells results in distinct affects on allergic inflammation in the lung, suggesting that these factors function in parallel. Together, these data define a role for ETV5 in Th9 development and extend the paradigm of related transcription factors having complementary functions during differentiation. Twit Text FOAVip The ETS family transcription factors Etv5 and PU 1 function in parallel to promote Th9 cell development ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27496971 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27496971 #FOAvip English Wikipedia <ref>{{Cite pmid|27496971}}</ref> The ETS family transcription factors Etv5 and PU 1 function in parallel to promote Th9 cell development #MMPMID27496971 Koh B; Hufford MM; Pham D; Olson MR; Wu T; Jabeen R; Sun X; Kaplan MH J Immunol 2016[Sep]; 197 (6): 2465-72 PMID27496971show ga The IL-9-secreting Th9 subset of CD4 T helper cells develop in response to an environment containing IL-4 and TGF?, promoting allergic disease, autoimmunity, and resistance to pathogens. We previously identified a requirement for the ETS family transcription factor PU.1 in Th9 development. In this report we demonstrate that the ETS transcription factor ETV5 promotes IL-9 production in Th9 cells by binding and recruiting histone acetyltransferases to the Il9 locus at sites distinct from PU.1. In cells that are deficient in both PU.1 and ETV5 there is lower IL-9 production than in cells lacking either factor alone. In vivo loss of PU.1 and ETV5 in T cells results in distinct affects on allergic inflammation in the lung, suggesting that these factors function in parallel. Together, these data define a role for ETV5 in Th9 development and extend the paradigm of related transcription factors having complementary functions during differentiation. äThe ETS family transcription factors Etv5 and PU 1 function in paralle(epmc).pdf DeepDyve Pubget Overpricing