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10.1007/s00441-016-2446-2 http://scihub22266oqcxt.onion/10.1007/s00441-016-2446-2 C5010935!5010935!27351421     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Tissue+Res 2016 ; 365 (3): 467-82 Nephropedia Template TP {{tp|p=27351421|t=2016. Integrin-mediated regulation of epidermal wound functions |pdf=|usr=}}{{27351421}} gab.com Text Integrin-mediated regulation of epidermal wound functions JO: Cell Tissue Res http://www.kidney.de/pget.php?&tw=1&pmid=27351421 #FOAvip During cutaneous wound healing, keratinocyte proliferation and migration are critical for re-epithelialization. In addition, the epidermis secretes growth factors, cytokines, proteases, and matricellular proteins into the wound microenvironment that modify the extracellular matrix and stimulate other wound cells that control the inflammatory response, promote angiogenesis, and facilitate tissue contraction and remodeling. Wound keratinocytes express at least seven different integrins - the major cell adhesion receptors for the extracellular matrix - that collectively control essential cell-autonomous functions to ensure proper re-epithelialization, including migration, proliferation, survival, and basement membrane assembly (Fig. 1, arrow 1). Moreover, it has become evident in recent years that some integrins can regulate paracrine signals from wound epidermis that stimulate other wound cells involved in angiogenesis, contraction and inflammation (Fig. 1, arrows 2 and 3). Importantly, it is likely that abnormal integrin expression or function in the epidermis contributes to wound pathologies such as over-exuberant healing (e.g., hypertrophic scar formation) or diminished healing (e.g., chronic wounds). In this review, we discuss current knowledge of integrin function in the epidermis, which implicates them as attractive therapeutic targets to promote wound healing or treat wound pathologies. We also discuss challenges that arise from the complex roles that multiple integrins play in wound epidermis, which may be regulated through extracellular matrix remodeling that determines ligand availability. Indeed, understanding how different integrin functions are temporally coordinated in wound epidermis, and which integrin functions go awry in pathological wounds, will be important to determine how best to target them clinically to achieve maximum therapeutic benefit. Twit Text FOAVip Integrin-mediated regulation of epidermal wound functions ????Cell Tissue Res http://www.kidney.de/pget.php?&tw=1&pmid=27351421 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27351421 #FOAvip English Wikipedia <ref>{{Cite pmid|27351421}}</ref> Integrin-mediated regulation of epidermal wound functions #MMPMID27351421 DiPersio CM; Zheng R; Kenney J; Van De Water L Cell Tissue Res 2016[Sep]; 365 (3): 467-82 PMID27351421show ga During cutaneous wound healing, keratinocyte proliferation and migration are critical for re-epithelialization. In addition, the epidermis secretes growth factors, cytokines, proteases, and matricellular proteins into the wound microenvironment that modify the extracellular matrix and stimulate other wound cells that control the inflammatory response, promote angiogenesis, and facilitate tissue contraction and remodeling. Wound keratinocytes express at least seven different integrins - the major cell adhesion receptors for the extracellular matrix - that collectively control essential cell-autonomous functions to ensure proper re-epithelialization, including migration, proliferation, survival, and basement membrane assembly (Fig. 1, arrow 1). Moreover, it has become evident in recent years that some integrins can regulate paracrine signals from wound epidermis that stimulate other wound cells involved in angiogenesis, contraction and inflammation (Fig. 1, arrows 2 and 3). Importantly, it is likely that abnormal integrin expression or function in the epidermis contributes to wound pathologies such as over-exuberant healing (e.g., hypertrophic scar formation) or diminished healing (e.g., chronic wounds). In this review, we discuss current knowledge of integrin function in the epidermis, which implicates them as attractive therapeutic targets to promote wound healing or treat wound pathologies. We also discuss challenges that arise from the complex roles that multiple integrins play in wound epidermis, which may be regulated through extracellular matrix remodeling that determines ligand availability. Indeed, understanding how different integrin functions are temporally coordinated in wound epidermis, and which integrin functions go awry in pathological wounds, will be important to determine how best to target them clinically to achieve maximum therapeutic benefit. äIntegrin-mediated regulation of epidermal wound functions (epmc).pdf DeepDyve Pubget Overpricing