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10.1186/s12915-016-0294-x http://scihub22266oqcxt.onion/10.1186/s12915-016-0294-x C5010735!5010735!27589901     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Biol 2016 ; 14 (1): ä Nephropedia Template TP {{tp|p=27589901|t=2016. Steering cell migration by alternating blebs and actin-rich protrusions |pdf=|usr=}}{{27589901}} gab.com Text Steering cell migration by alternating blebs and actin-rich protrusions JO: BMC Biol http://www.kidney.de/pget.php?&tw=1&pmid=27589901 #FOAvip Background: High directional persistence is often assumed to enhance the efficiency of chemotactic migration. Yet, cells in vivo usually display meandering trajectories with relatively low directional persistence, and the control and function of directional persistence during cell migration in three-dimensional environments are poorly understood. Results: Here, we use mesendoderm progenitors migrating during zebrafish gastrulation as a model system to investigate the control of directional persistence during migration in vivo. We show that progenitor cells alternate persistent run phases with tumble phases that result in cell reorientation. Runs are characterized by the formation of directed actin-rich protrusions and tumbles by enhanced blebbing. Increasing the proportion of actin-rich protrusions or blebs leads to longer or shorter run phases, respectively. Importantly, both reducing and increasing run phases result in larger spatial dispersion of the cells, indicative of reduced migration precision. A physical model quantitatively recapitulating the migratory behavior of mesendoderm progenitors indicates that the ratio of tumbling to run times, and thus the specific degree of directional persistence of migration, are critical for optimizing migration precision. Conclusions: Together, our experiments and model provide mechanistic insight into the control of migration directionality for cells moving in three-dimensional environments that combine different protrusion types, whereby the proportion of blebs to actin-rich protrusions determines the directional persistence and precision of movement by regulating the ratio of tumbling to run times. Electronic supplementary material: The online version of this article (doi:10.1186/s12915-016-0294-x) contains supplementary material, which is available to authorized users. Twit Text FOAVip Steering cell migration by alternating blebs and actin-rich protrusions ????BMC Biol http://www.kidney.de/pget.php?&tw=1&pmid=27589901 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27589901 #FOAvip English Wikipedia <ref>{{Cite pmid|27589901}}</ref> Steering cell migration by alternating blebs and actin-rich protrusions #MMPMID27589901 Diz-Muņoz A; Romanczuk P; Yu W; Bergert M; Ivanovitch K; Salbreux G; Heisenberg CP; Paluch EK BMC Biol 2016[]; 14 (1): ä PMID27589901show ga Background: High directional persistence is often assumed to enhance the efficiency of chemotactic migration. Yet, cells in vivo usually display meandering trajectories with relatively low directional persistence, and the control and function of directional persistence during cell migration in three-dimensional environments are poorly understood. Results: Here, we use mesendoderm progenitors migrating during zebrafish gastrulation as a model system to investigate the control of directional persistence during migration in vivo. We show that progenitor cells alternate persistent run phases with tumble phases that result in cell reorientation. Runs are characterized by the formation of directed actin-rich protrusions and tumbles by enhanced blebbing. Increasing the proportion of actin-rich protrusions or blebs leads to longer or shorter run phases, respectively. Importantly, both reducing and increasing run phases result in larger spatial dispersion of the cells, indicative of reduced migration precision. A physical model quantitatively recapitulating the migratory behavior of mesendoderm progenitors indicates that the ratio of tumbling to run times, and thus the specific degree of directional persistence of migration, are critical for optimizing migration precision. Conclusions: Together, our experiments and model provide mechanistic insight into the control of migration directionality for cells moving in three-dimensional environments that combine different protrusion types, whereby the proportion of blebs to actin-rich protrusions determines the directional persistence and precision of movement by regulating the ratio of tumbling to run times. Electronic supplementary material: The online version of this article (doi:10.1186/s12915-016-0294-x) contains supplementary material, which is available to authorized users. äSteering cell migration by alternating blebs and actin-rich protrusion(epmc).pdf DeepDyve Pubget Overpricing