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10.1186/s12967-016-1008-4 http://scihub22266oqcxt.onion/10.1186/s12967-016-1008-4 C5010719!5010719!27590450     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Transl+Med 2016 ; 14 (1): ä Nephropedia Template TP {{tp|p=27590450|t=2016. Ockham?s razor for the MET-driven invasive growth linking idiopathic pulmonary fibrosis and cancer |pdf=|usr=}}{{27590450}} gab.com Text Ockham s razor for the MET-driven invasive growth linking idiopathic pulmonary fibrosis and cancer JO: J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=27590450 #FOAvip Background: Idiopathic pulmonary fibrosis (IPF) identifies a specific lung disorder characterized by chronic, progressive fibrosing interstitial pneumonia of unknown etiology, which lacks effective treatment. According to the current pathogenic perspective, the aberrant proliferative events in IPF resemble those occurring during malignant transformation. Main body: Receptor tyrosine kinases (RTK) are known to be key players in cancer onset and progression. It has been demonstrated that RTK expression is sometimes also altered and even druggable in IPF. One example of an RTK?the MET proto-oncogene?is a key regulator of invasive growth. This physiological genetic program supports embryonic development and post-natal organ regeneration, as well as cooperating in the evolution of cancer metastasis when aberrantly activated. Growing evidence sustains that MET activation may collaborate in maintaining tissue plasticity and the regenerative potential that characterizes IPF. Conclusion: The present work aims to elucidate?by applying the logic of simplicity?the bio-molecular mechanisms involved in MET activation in IPF. This clarification is crucial to accurately design MET blockade strategies within a fully personalized approach to IPF. Twit Text FOAVip Ockham s razor for the MET-driven invasive growth linking idiopathic pulmonary fibrosis and cancer ????J Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=27590450 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27590450 #FOAvip English Wikipedia <ref>{{Cite pmid|27590450}}</ref> Ockham?s razor for the MET-driven invasive growth linking idiopathic pulmonary fibrosis and cancer #MMPMID27590450 Stella GM; Gentile A; Baderacchi A; Meloni F; Milan M; Benvenuti S J Transl Med 2016[]; 14 (1): ä PMID27590450show ga Background: Idiopathic pulmonary fibrosis (IPF) identifies a specific lung disorder characterized by chronic, progressive fibrosing interstitial pneumonia of unknown etiology, which lacks effective treatment. According to the current pathogenic perspective, the aberrant proliferative events in IPF resemble those occurring during malignant transformation. Main body: Receptor tyrosine kinases (RTK) are known to be key players in cancer onset and progression. It has been demonstrated that RTK expression is sometimes also altered and even druggable in IPF. One example of an RTK?the MET proto-oncogene?is a key regulator of invasive growth. This physiological genetic program supports embryonic development and post-natal organ regeneration, as well as cooperating in the evolution of cancer metastasis when aberrantly activated. Growing evidence sustains that MET activation may collaborate in maintaining tissue plasticity and the regenerative potential that characterizes IPF. Conclusion: The present work aims to elucidate?by applying the logic of simplicity?the bio-molecular mechanisms involved in MET activation in IPF. This clarification is crucial to accurately design MET blockade strategies within a fully personalized approach to IPF. äOckham?s razor for the MET-driven invasive growth linking idiopathic p(epmc).pdf DeepDyve Pubget Overpricing