Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1186/s13071-016-1770-4 http://scihub22266oqcxt.onion/10.1186/s13071-016-1770-4 C5010673!5010673!27589866     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Parasit+Vectors 2016 ; 9 (1): ä Nephropedia Template TP {{tp|p=27589866|t=2016. Wnt signaling in regulation of biological functions of the nurse cell harboring Trichinella spp |pdf=|usr=}}{{27589866}} gab.com Text Wnt signaling in regulation of biological functions of the nurse cell harboring Trichinella spp JO: Parasit Vectors http://www.kidney.de/pget.php?&tw=1&pmid=27589866 #FOAvip Background: The nurse cell (NC) constitutes in mammalian skeletal muscles a confined intracellular niche to support the metabolic needs of muscle larvae of Trichinella spp. encapsulating species. The main biological functions of NC were identified as hypermitogenic growth arrest and pro-inflammatory phenotype, both inferred to depend on AP-1 (activator protein 1) transcription factor. Since those functions, as well as AP-1 activity, are known to be regulated among other pathways, also by Wnt (Wingless-Type of Mouse Mammary Tumor Virus Integration Site) signaling, transcription profiling of molecules participating in Wnt signaling cascades in NC, was performed. Methods: Wnt signaling-involved gene expression level was measured by quantitative RT-PCR approach with the use of Qiagen RT2 Profiler PCR Arrays and complemented by that obtained by searching microarray data sets characterizing NC transcriptome. Results: The genes involved in inhibition of canonical Wnt/?-catenin signaling cascade as well as leading to ?-catenin degradation were found expressed in NC at high level, indicating inhibition of this cascade activity. High expression in NC of genes transmitting the signal of Wnt non-canonical signaling cascades leading to activation of AP-1 transcription factor, points to predominant role of non-canonical Wnt signaling in a long term maintenance of NC biological functions. Conclusions: Canonical Wnt/?-catenin signaling cascade is postulated to play a role at the early stages of NC formation when muscle regeneration process is triggered. Following mis-differentiation of infected myofiber and setting of NC functional specificity, are inferred to be controlled among other pathways, by Wnt non-canonical signaling cascades. Electronic supplementary material: The online version of this article (doi:10.1186/s13071-016-1770-4) contains supplementary material, which is available to authorized users. Twit Text FOAVip Wnt signaling in regulation of biological functions of the nurse cell harboring Trichinella spp ????Parasit Vectors http://www.kidney.de/pget.php?&tw=1&pmid=27589866 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27589866 #FOAvip English Wikipedia <ref>{{Cite pmid|27589866}}</ref> Wnt signaling in regulation of biological functions of the nurse cell harboring Trichinella spp #MMPMID27589866 Dabrowska M; Skoneczny M; Zielinski Z; Rode W Parasit Vectors 2016[]; 9 (1): ä PMID27589866show ga Background: The nurse cell (NC) constitutes in mammalian skeletal muscles a confined intracellular niche to support the metabolic needs of muscle larvae of Trichinella spp. encapsulating species. The main biological functions of NC were identified as hypermitogenic growth arrest and pro-inflammatory phenotype, both inferred to depend on AP-1 (activator protein 1) transcription factor. Since those functions, as well as AP-1 activity, are known to be regulated among other pathways, also by Wnt (Wingless-Type of Mouse Mammary Tumor Virus Integration Site) signaling, transcription profiling of molecules participating in Wnt signaling cascades in NC, was performed. Methods: Wnt signaling-involved gene expression level was measured by quantitative RT-PCR approach with the use of Qiagen RT2 Profiler PCR Arrays and complemented by that obtained by searching microarray data sets characterizing NC transcriptome. Results: The genes involved in inhibition of canonical Wnt/?-catenin signaling cascade as well as leading to ?-catenin degradation were found expressed in NC at high level, indicating inhibition of this cascade activity. High expression in NC of genes transmitting the signal of Wnt non-canonical signaling cascades leading to activation of AP-1 transcription factor, points to predominant role of non-canonical Wnt signaling in a long term maintenance of NC biological functions. Conclusions: Canonical Wnt/?-catenin signaling cascade is postulated to play a role at the early stages of NC formation when muscle regeneration process is triggered. Following mis-differentiation of infected myofiber and setting of NC functional specificity, are inferred to be controlled among other pathways, by Wnt non-canonical signaling cascades. Electronic supplementary material: The online version of this article (doi:10.1186/s13071-016-1770-4) contains supplementary material, which is available to authorized users. äWnt signaling in regulation of biological functions of the nurse cell (epmc).pdf DeepDyve Pubget Overpricing