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10.1158/2159-8290.CD-15-1227 http://scihub22266oqcxt.onion/10.1158/2159-8290.CD-15-1227 C5010513!5010513!27432226     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 296.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Discov 2016 ; 6 (9): 1052-67 Nephropedia Template TP {{tp|p=27432226|t=2016. Genome-wide Meta-analyses of Breast, Ovarian and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by At Least Two Cancer Types |pdf=|usr=}}{{27432226}} gab.com Text Genome-wide Meta-analyses of Breast, Ovarian and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by At Least Two Cancer Types JO: Cancer Discov http://www.kidney.de/pget.php?&tw=1&pmid=27432226 #FOAvip Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10?8 seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11; rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/SMC2; rs8037137/15q26/RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p34/NSUN4; rs9375701/6q23/L3MBTL3). Index variants in five additional regions previously associated with only one cancer also showed clear association with a second cancer type. Cell-type specific expression quantitative trait locus and enhancer-gene interaction annotations suggested target genes with potential cross-cancer roles at the new loci. Pathway analysis revealed significant enrichment of death receptor signaling genes near loci with P < 10?5 in the three-cancer meta-analysis. Twit Text FOAVip Genome-wide Meta-analyses of Breast, Ovarian and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by At Least Two Cancer Types ????Cancer Discov http://www.kidney.de/pget.php?&tw=1&pmid=27432226 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27432226 #FOAvip English Wikipedia <ref>{{Cite pmid|27432226}}</ref> Genome-wide Meta-analyses of Breast, Ovarian and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by At Least Two Cancer Types #MMPMID27432226 Kar SP; Beesley J; Al Olama AA; Michailidou K; Tyrer J; Kote-Jarai Z; Lawrenson K; Lindstrom S; Ramus SJ; Thompson DJ; Kibel AS; Dansonka-Mieszkowska A; Michael A; Dieffenbach AK; Gentry-Maharaj A; Whittemore AS; Wolk A; Monteiro A; Peixoto A; Kierzek A; Cox A; Rudolph A; Gonzalez-Neira A; Wu AH; Lindblom A; Swerdlow A; Ziogas A; Ekici AB; Burwinkel B; Karlan BY; Nordestgaard BG; Blomqvist C; Phelan C; McLean C; Pearce CL; Vachon C; Cybulski C; Slavov C; Stegmaier C; Maier C; Ambrosone CB; Høgdall CK; Teerlink CC; Kang D; Tessier DC; Schaid DJ; Stram DO; Cramer DW; Neal DE; Eccles D; Flesch-Janys D; Velez Edwards DR; Wokozorczyk D; Levine DA; Yannoukakos D; Sawyer EJ; Bandera EV; Poole EM; Goode EL; Khusnutdinova E; Høgdall E; Song F; Bruinsma F; Heitz F; Modugno F; Hamdy FC; Wiklund F; Giles GG; Olsson H; Wildiers H; Ulmer HU; Pandha H; Risch HA; Darabi H; Salvesen HB; Nevanlinna H; Gronberg H; Brenner H; Brauch H; Anton-Culver H; Song H; Lim HY; McNeish I; Campbell I; Vergote I; Gronwald J; Lubi?ski J; Stanford JL; Benítez J; Doherty JA; Permuth JB; Chang-Claude J; Donovan JL; Dennis J; Schildkraut JM; Schleutker J; Hopper JL; Kupryjanczyk J; Park JY; Figueroa J; Clements JA; Knight JA; Peto J; Cunningham JM; Pow-Sang J; Batra J; Czene K; Lu KH; Herkommer K; Khaw KT; Matsuo K; Muir K; Offitt K; Chen K; Moysich KB; Aittomäki K; Odunsi K; Kiemeney LA; Massuger LF; Fitzgerald LM; Cook LS; Cannon-Albright L; Hooning MJ; Pike MC; Bolla MK; Luedeke M; Teixeira MR; Goodman MT; Schmidt MK; Riggan M; Aly M; Rossing MA; Beckmann MW; Moisse M; Sanderson M; Southey MC; Jones M; Lush M; Hildebrandt MAT; Hou MF; Schoemaker MJ; Garcia-Closas M; Bogdanova N; Rahman N; Le ND; Orr N; Wentzensen N; Pashayan N; Peterlongo P; Guénel P; Brennan P; Paulo P; Webb PM; Broberg P; Fasching PA; Devilee P; Wang Q; Cai Q; Li Q; Kaneva R; Butzow R; Kopperud RK; Schmutzler RK; Stephenson RA; MacInnis RJ; Hoover RN; Winqvist R; Ness R; Milne RL; Travis RC; Benlloch S; Olson SH; McDonnell SK; Tworoger SS; Maia S; Berndt S; Lee SC; Teo SH; Thibodeau SN; Bojesen SE; Gapstur SM; Kjær SK; Pejovic T; Tammela TL; Dörk T; Brüning T; Wahlfors T; Key TJ; Edwards TL; Menon U; Hamann U; Mitev V; Kosma VM; Setiawan VW; Kristensen V; Arndt V; Vogel W; Zheng W; Sieh W; Blot WJ; Kluzniak W; Shu XO; Gao YT; Schumacher F; Freedman ML; Berchuck A; Dunning AM; Simard J; Haiman CA; Spurdle A; Sellers TA; Hunter DJ; Henderson BE; Kraft P; Chanock SJ; Couch FJ; Hall P; Gayther SA; Easton DF; Chenevix-Trench G; Eeles R; Pharoah PD; Lambrechts D Cancer Discov 2016[Sep]; 6 (9): 1052-67 PMID27432226show ga Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10?8 seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11; rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/SMC2; rs8037137/15q26/RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p34/NSUN4; rs9375701/6q23/L3MBTL3). Index variants in five additional regions previously associated with only one cancer also showed clear association with a second cancer type. Cell-type specific expression quantitative trait locus and enhancer-gene interaction annotations suggested target genes with potential cross-cancer roles at the new loci. Pathway analysis revealed significant enrichment of death receptor signaling genes near loci with P < 10?5 in the three-cancer meta-analysis. äGenome-wide Meta-analyses of Breast, Ovarian and Prostate Cancer Assoc(epmc).pdf DeepDyve Pubget Overpricing