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10.1158/0008-5472.CAN-16-0726 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-16-0726 C5010508!5010508!27520450     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2016 ; 76 (17): 4918-23 Nephropedia Template TP {{tp|p=27520450|t=2016. Somatic engineering of oncogenic chromosomal rearrangements: a perspective |pdf=|usr=}}{{27520450}} gab.com Text Somatic engineering of oncogenic chromosomal rearrangements: a perspective JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27520450 #FOAvip The ability to engineer specific mutations in mice has proven essential to advancing our understanding of the molecular basis of cancer. Chromosomal rearrangements, a common and clinically relevant class of cancer-causing mutations, have however remained difficult to faithfully recapitulate in vivo. The development of genetic tools for in vivo somatic genome editing has recently overcome this limitation and led to the generation of more sophisticated and accurate preclinical models of human cancers. Here we review the potential applications of these new technologies to the study of tumor biology and discuss their advantages over more conventional strategies, their limitations, and the remaining challenges. Twit Text FOAVip Somatic engineering of oncogenic chromosomal rearrangements: a perspective ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27520450 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27520450 #FOAvip English Wikipedia <ref>{{Cite pmid|27520450}}</ref> Somatic engineering of oncogenic chromosomal rearrangements: a perspective #MMPMID27520450 Maddalo D; Ventura A Cancer Res 2016[Sep]; 76 (17): 4918-23 PMID27520450show ga The ability to engineer specific mutations in mice has proven essential to advancing our understanding of the molecular basis of cancer. Chromosomal rearrangements, a common and clinically relevant class of cancer-causing mutations, have however remained difficult to faithfully recapitulate in vivo. The development of genetic tools for in vivo somatic genome editing has recently overcome this limitation and led to the generation of more sophisticated and accurate preclinical models of human cancers. Here we review the potential applications of these new technologies to the study of tumor biology and discuss their advantages over more conventional strategies, their limitations, and the remaining challenges. äSomatic engineering of oncogenic chromosomal rearrangements: a perspec(epmc).pdf DeepDyve Pubget Overpricing