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10.1158/0008-5472.CAN-15-2980 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-15-2980 C5010493!5010493!27197191     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2016 ; 76 (17): 5103-14 Nephropedia Template TP {{tp|p=27197191|t=2016. Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations |pdf=|usr=}}{{27197191}} gab.com Text Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27197191 #FOAvip Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-staged approach to conduct genome-wide association studies for lung, ovary, breast, prostate and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. Twit Text FOAVip Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27197191 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27197191 #FOAvip English Wikipedia <ref>{{Cite pmid|27197191}}</ref> Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations #MMPMID27197191 Fehringer G; Kraft P; Pharoah PD; Eeles RA; Chatterjee N; Schumacher F; Schildkraut J; Lindström S; Brennan P; Bickeböller H; Houlston RS; Landi MT; Caporaso N; Risch A; Olama AAA; Berndt SI; Giovannucci E; Grönberg H; Kote-Jarai Z; Ma J; Muir K; Stampfer M; Stevens VL; Wiklund F; Willett W; Goode EL; Permuth J; Risch HA; Reid BM; Bezieau S; Brenner H; Chan AT; Chang-Claude J; Hudson TJ; Kocarnik JK; Newcomb PA; Schoen RE; Slattery ML; White E; Adank MA; Ahsan H; Aittomäki K; Baglietto L; Blomquist C; Canzian F; Czene K; dos-Santos-Silva I; Eliassen AH; Figueroa J; Flesch-Janys D; Fletcher O; Garcia-Closas M; Gaudet MM; Johnson N; Hall P; Hazra A; Hein R; Hofman A; Hopper JL; Irwanto A; Johansson M; Kaaks R; Kibriya MG; Lichtner P; Liu J; Lund E; Makalic E; Meindl A; Müller-Myhsok B; Muranen TA; Nevanlinna H; Peeters PH; Peto J; Prentice RL; Rahman N; Sanchez MJ; Schmidt DF; Schmutzler RK; Southey MC; Tamimi R; Travis RC; Turnbull C; Uitterlinden AG; Wang Z; Whittemore AS; Yang XR; Zheng W; Rafnar T; Gudmundsson J; Stacey SN; Stefansson K; Sulem P; Chen YA; Tyrer JP; Christiani DC; Wei Y; Shen H; Hu Z; Shu XO; Shiraishi K; Takahashi A; Bossé Y; Obeidat M; Nickle D; Timens W; Freedman ML; Li Q; Seminara D; Chanock SJ; Gong J; Peters U; Gruber SB; Amos CI; Sellers TA; Easton DF; Hunter DJ; Haiman CA; Henderson BE; Hung RJ Cancer Res 2016[Sep]; 76 (17): 5103-14 PMID27197191show ga Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-staged approach to conduct genome-wide association studies for lung, ovary, breast, prostate and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression. äCross-cancer genome-wide analysis of lung, ovary, breast, prostate and(epmc).pdf DeepDyve Pubget Overpricing