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Transcriptional Regulation of Mast Cell and Basophil Lineage Commitment #MMPMID27126100
Huang H; Li Y; Liu B
Semin Immunopathol 2016[Sep]; 38 (5): 539-48 PMID27126100show ga
Basophils and mast cells have long been known to play critical roles in allergic disease and in immunity against parasitic infection. Accumulated evidence supports that basophils and mast cells also have important roles in immune regulations, host defense against bacteria and viruses, and autoimmune diseases. However, origin and molecular regulation of basophil and mast cell differentiation remain incompletely understood. In this review, we focus on recent advances in the understanding of origin and molecular regulation of mouse and human basophil and mast cell development. A more complete understanding of how basophils and mast cells develop at the molecular level will lead to development of interventions that are more effective in achieving long-term success.