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2016 ; 27
(3
): 238-52
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ST2 and Galectin-3: Ready for Prime Time?
#MMPMID27683537
Meijers WC
; van der Velde AR
; de Boer RA
EJIFCC
2016[Aug]; 27
(3
): 238-52
PMID27683537
show ga
ST2 and galectin-3 are emerging biomarkers in the field of heart failure and have
been extensively studied, and that whether they provide additional prognostic
value on top of the clinical models and the gold standard in HF, (NT-pro)BNP. Our
aim was to provide a comprehensive review of these emerging HF-related biomarkers
in chronic, acute and incident heart failure. Regardless of the type of heart
failure, both biomarkers seem to have an additional effect on top of the clinical
model including natriuretic peptides. Strategies that combine multiple biomarkers
may ultimately prove to be beneficial in the guidance of HF therapy in the
future. However, additional prognostic value appears to be limited, and what we
need is to prospectively test the consistent observations, which then might lead
to the implementation of ST2 and galectin-3 in heart failure algorithms.