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10.4049/jimmunol.1600990 http://scihub22266oqcxt.onion/10.4049/jimmunol.1600990 C5009878!5009878 !27527598     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27527598 &cmd=llinks): Failed to open stream: HTTP request failed! 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Unconventional Human T Cells Accumulate at the Site of Infection in Response to Microbial Ligands and Induce Local Tissue Remodeling |pdf=|usr=}}{{27527598 }} gab.com Text Unconventional Human T Cells Accumulate at the Site of Infection in Response to Microbial Ligands and Induce Local Tissue Remodeling JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27527598 #FOAvip The antimicrobial responsiveness and function of unconventional human T cells are poorly understood, with only limited access to relevant specimens from sites of infection. Peritonitis is a common and serious complication in individuals with end-stage kidney disease receiving peritoneal dialysis. By analyzing local and systemic immune responses in peritoneal dialysis patients presenting with acute bacterial peritonitis and monitoring individuals before and during defined infectious episodes, our data show that V?9/V?2(+) ?? T cells and mucosal-associated invariant T cells accumulate at the site of infection with organisms producing (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate and vitamin B2, respectively. Such unconventional human T cells are major producers of IFN-? and TNF-? in response to these ligands that are shared by many microbial pathogens and affect the cells lining the peritoneal cavity by triggering local inflammation and inducing tissue remodeling with consequences for peritoneal membrane integrity. Our data uncover a crucial role for V?9/V?2 T cells and mucosal-associated invariant T cells in bacterial infection and suggest that they represent a useful predictive marker for important clinical outcomes, which may inform future stratification and patient management. These findings are likely to be applicable to other acute infections where local activation of unconventional T cells contributes to the antimicrobial inflammatory response. Twit Text FOAVip Unconventional Human T Cells Accumulate at the Site of Infection in Response to Microbial Ligands and Induce Local Tissue Remodeling ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27527598 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27527598 #FOAvip English Wikipedia <ref>{{Cite pmid|27527598 }}</ref> Unconventional Human T Cells Accumulate at the Site of Infection in Response to Microbial Ligands and Induce Local Tissue Remodeling #MMPMID27527598 Liuzzi AR ; Kift-Morgan A ; Lopez-Anton M ; Friberg IM ; Zhang J ; Brook AC ; Roberts GW ; Donovan KL ; Colmont CS ; Toleman MA ; Bowen T ; Johnson DW ; Topley N ; Moser B ; Fraser DJ ; Eberl M J Immunol 2016[Sep]; 197 (6 ): 2195-207 PMID27527598 show ga The antimicrobial responsiveness and function of unconventional human T cells are poorly understood, with only limited access to relevant specimens from sites of infection. Peritonitis is a common and serious complication in individuals with end-stage kidney disease receiving peritoneal dialysis. By analyzing local and systemic immune responses in peritoneal dialysis patients presenting with acute bacterial peritonitis and monitoring individuals before and during defined infectious episodes, our data show that V?9/V?2(+) ?? T cells and mucosal-associated invariant T cells accumulate at the site of infection with organisms producing (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate and vitamin B2, respectively. Such unconventional human T cells are major producers of IFN-? and TNF-? in response to these ligands that are shared by many microbial pathogens and affect the cells lining the peritoneal cavity by triggering local inflammation and inducing tissue remodeling with consequences for peritoneal membrane integrity. Our data uncover a crucial role for V?9/V?2 T cells and mucosal-associated invariant T cells in bacterial infection and suggest that they represent a useful predictive marker for important clinical outcomes, which may inform future stratification and patient management. These findings are likely to be applicable to other acute infections where local activation of unconventional T cells contributes to the antimicrobial inflammatory response. |Bacterial Infections/*immunology/pathology [MESH] |Cell Movement [MESH] |Epithelial-Mesenchymal Transition [MESH] |Humans [MESH] |Interferon-gamma/biosynthesis [MESH] |Ligands [MESH] |Neutrophil Infiltration [MESH] |Peritonitis/immunology [MESH] |T-Lymphocytes/*physiology [MESH]Unconventional Human T Cells Accumulate at the Site of Infection in Re(epmc).pdf DeepDyve Pubget Overpricing