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10.15252/emmm.201606198 http://scihub22266oqcxt.onion/10.15252/emmm.201606198 C5009810!5009810!27485121     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Mol+Med 2016 ; 8 (9): 1052-64 Nephropedia Template TP {{tp|p=27485121|t=2016. LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer |pdf=|usr=}}{{27485121}} gab.com Text LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27485121 #FOAvip Long noncoding RNAs (lncRNAs) are emerging as regulators of gene expression in pathogenesis, including cancer. Recently, lncRNAs have been implicated in progression of specific subtypes of breast cancer. One aggressive, basal?like subtype associates with increased EGFR signaling, while another, the HER2?enriched subtype, engages a kin of EGFR. Based on the premise that EGFR?regulated lncRNAs might control the aggressiveness of basal?like tumors, we identified multiple EGFR?inducible lncRNAs in basal?like normal cells and overlaid them with the transcriptomes of over 3,000 breast cancer patients. This led to the identification of 11 prognostic lncRNAs. Functional analyses of this group uncovered LINC01089 (here renamed LncRNA Inhibiting Metastasis; LIMT), a highly conserved lncRNA, which is depleted in basal?like and in HER2?positive tumors, and the low expression of which predicts poor patient prognosis. Interestingly, EGF rapidly downregulates LIMT expression by enhancing histone deacetylation at the respective promoter. We also find that LIMT inhibits extracellular matrix invasion of mammary cells in vitro and tumor metastasis in vivo. In conclusion, lncRNAs dynamically regulated by growth factors might act as novel drivers of cancer progression and serve as prognostic biomarkers. Twit Text FOAVip LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27485121 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27485121 #FOAvip English Wikipedia <ref>{{Cite pmid|27485121}}</ref> LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer #MMPMID27485121 Sas?Chen A; Aure MR; Leibovich L; Carvalho S; Enuka Y; Körner C; Polycarpou?Schwarz M; Lavi S; Nevo N; Kuznetsov Y; Yuan J; Azuaje F; Ulitsky I; Diederichs S; Wiemann S; Yakhini Z; Kristensen VN; Børresen?Dale A; Yarden Y; Sauer T; Geisler J; Hofvind S; Bathen TF; Borgen E; Engebråten O; Fodstad Ø; Garred Ø; Geitvik GA; Kåresen R; Naume B; Mælandsmo GM; Russnes HG; Schlichting E; Sørlie T; Lingjærde OC; Sahlberg KK; Skjerven HK; Fritzman B EMBO Mol Med 2016[Sep]; 8 (9): 1052-64 PMID27485121show ga Long noncoding RNAs (lncRNAs) are emerging as regulators of gene expression in pathogenesis, including cancer. Recently, lncRNAs have been implicated in progression of specific subtypes of breast cancer. One aggressive, basal?like subtype associates with increased EGFR signaling, while another, the HER2?enriched subtype, engages a kin of EGFR. Based on the premise that EGFR?regulated lncRNAs might control the aggressiveness of basal?like tumors, we identified multiple EGFR?inducible lncRNAs in basal?like normal cells and overlaid them with the transcriptomes of over 3,000 breast cancer patients. This led to the identification of 11 prognostic lncRNAs. Functional analyses of this group uncovered LINC01089 (here renamed LncRNA Inhibiting Metastasis; LIMT), a highly conserved lncRNA, which is depleted in basal?like and in HER2?positive tumors, and the low expression of which predicts poor patient prognosis. Interestingly, EGF rapidly downregulates LIMT expression by enhancing histone deacetylation at the respective promoter. We also find that LIMT inhibits extracellular matrix invasion of mammary cells in vitro and tumor metastasis in vivo. In conclusion, lncRNAs dynamically regulated by growth factors might act as novel drivers of cancer progression and serve as prognostic biomarkers. äLIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and dow(epmc).pdf DeepDyve Pubget Overpricing