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10.15252/emmm.201506164 http://scihub22266oqcxt.onion/10.15252/emmm.201506164 C5009809!5009809 !27406819     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27406819 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+Mol+Med 2016 ; 8 (9 ): 1039-51 Nephropedia Template TP {{tp|p=27406819 |t=2016. Prolonged contact with dendritic cells turns lymph node-resident NK cells into anti-tumor effectors |pdf=|usr=}}{{27406819 }} gab.com Text Prolonged contact with dendritic cells turns lymph node-resident NK cells into anti-tumor effectors JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27406819 #FOAvip Natural killer (NK) cells are critical players against tumors. The outcome of anti-tumor vaccination protocols depends on the efficiency of NK-cell activation, and efforts are constantly made to manipulate them for immunotherapeutic approaches. Thus, a better understanding of NK-cell activation dynamics is needed. NK-cell interactions with accessory cells and trafficking between secondary lymphoid organs and tumoral tissues remain poorly characterized. Here, we show that upon triggering innate immunity with lipopolysaccharide (LPS), NK cells are transiently activated, leave the lymph node, and infiltrate the tumor, delaying its growth. Interestingly, NK cells are not actively recruited at the draining lymph node early after LPS administration, but continue their regular homeostatic turnover. Therefore, NK cells resident in the lymph node at the time of LPS administration become activated and exert anti-tumor functions. NK-cell activation correlates with the establishment of prolonged interactions with dendritic cells (DCs) in lymph nodes, as observed by two-photon microscopy. Close DC and NK-cell contacts are essential for the localized delivery of DC-derived IL-18 to NK cells, a strict requirement in NK-cell activation. Twit Text FOAVip Prolonged contact with dendritic cells turns lymph node-resident NK cells into anti-tumor effectors ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27406819 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27406819 #FOAvip English Wikipedia <ref>{{Cite pmid|27406819 }}</ref> Prolonged contact with dendritic cells turns lymph node-resident NK cells into anti-tumor effectors #MMPMID27406819 Mingozzi F ; Spreafico R ; Gorletta T ; Cigni C ; Di Gioia M ; Caccia M ; Sironi L ; Collini M ; Soncini M ; Rusconi M ; von Andrian UH ; Chirico G ; Zanoni I ; Granucci F EMBO Mol Med 2016[Sep]; 8 (9 ): 1039-51 PMID27406819 show ga Natural killer (NK) cells are critical players against tumors. The outcome of anti-tumor vaccination protocols depends on the efficiency of NK-cell activation, and efforts are constantly made to manipulate them for immunotherapeutic approaches. Thus, a better understanding of NK-cell activation dynamics is needed. NK-cell interactions with accessory cells and trafficking between secondary lymphoid organs and tumoral tissues remain poorly characterized. Here, we show that upon triggering innate immunity with lipopolysaccharide (LPS), NK cells are transiently activated, leave the lymph node, and infiltrate the tumor, delaying its growth. Interestingly, NK cells are not actively recruited at the draining lymph node early after LPS administration, but continue their regular homeostatic turnover. Therefore, NK cells resident in the lymph node at the time of LPS administration become activated and exert anti-tumor functions. NK-cell activation correlates with the establishment of prolonged interactions with dendritic cells (DCs) in lymph nodes, as observed by two-photon microscopy. Close DC and NK-cell contacts are essential for the localized delivery of DC-derived IL-18 to NK cells, a strict requirement in NK-cell activation. |Animals [MESH] |Dendritic Cells/*immunology [MESH] |Disease Models, Animal [MESH] |Killer Cells, Natural/*immunology [MESH] |Lipopolysaccharides/administration & dosage/immunology [MESH] |Lymph Nodes/*immunology [MESH] |Lymphocyte Activation [MESH] |Mice [MESH]Prolonged contact with dendritic cells turns lymph node-resident NK ce(epmc).pdf DeepDyve Pubget Overpricing