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10.1093/nar/gkw323 http://scihub22266oqcxt.onion/10.1093/nar/gkw323 C5009722!5009722 !27112571     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27112571 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nucleic+Acids+Res 2016 ; 44 (15 ): 7144-58 Nephropedia Template TP {{tp|p=27112571 |t=2016. HMGN proteins modulate chromatin regulatory sites and gene expression during activation of naïve B cells |pdf=|usr=}}{{27112571 }} gab.com Text HMGN proteins modulate chromatin regulatory sites and gene expression during activation of naïve B cells JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=27112571 #FOAvip The activation of naïve B lymphocyte involves rapid and major changes in chromatin organization and gene expression; however, the complete repertoire of nuclear factors affecting these genomic changes is not known. We report that HMGN proteins, which bind to nucleosomes and affect chromatin structure and function, co-localize with, and maintain the intensity of DNase I hypersensitive sites genome wide, in resting but not in activated B cells. Transcription analyses of resting and activated B cells from wild-type and Hmgn(-/-) mice, show that loss of HMGNs dampens the magnitude of the transcriptional response and alters the pattern of gene expression during the course of B-cell activation; defense response genes are most affected at the onset of activation. Our study provides insights into the biological function of the ubiquitous HMGN chromatin binding proteins and into epigenetic processes that affect the fidelity of the transcriptional response during the activation of B cell lymphocytes. Twit Text FOAVip HMGN proteins modulate chromatin regulatory sites and gene expression during activation of naïve B cells ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=27112571 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27112571 #FOAvip English Wikipedia <ref>{{Cite pmid|27112571 }}</ref> HMGN proteins modulate chromatin regulatory sites and gene expression during activation of naïve B cells #MMPMID27112571 Zhang S ; Zhu I ; Deng T ; Furusawa T ; Rochman M ; Vacchio MS ; Bosselut R ; Yamane A ; Casellas R ; Landsman D ; Bustin M Nucleic Acids Res 2016[Sep]; 44 (15 ): 7144-58 PMID27112571 show ga The activation of naïve B lymphocyte involves rapid and major changes in chromatin organization and gene expression; however, the complete repertoire of nuclear factors affecting these genomic changes is not known. We report that HMGN proteins, which bind to nucleosomes and affect chromatin structure and function, co-localize with, and maintain the intensity of DNase I hypersensitive sites genome wide, in resting but not in activated B cells. Transcription analyses of resting and activated B cells from wild-type and Hmgn(-/-) mice, show that loss of HMGNs dampens the magnitude of the transcriptional response and alters the pattern of gene expression during the course of B-cell activation; defense response genes are most affected at the onset of activation. Our study provides insights into the biological function of the ubiquitous HMGN chromatin binding proteins and into epigenetic processes that affect the fidelity of the transcriptional response during the activation of B cell lymphocytes. |*Gene Expression Regulation [MESH] |Animals [MESH] |B-Lymphocytes/cytology/immunology/*metabolism [MESH] |Chromatin/*genetics/*metabolism [MESH] |Deoxyribonuclease I/metabolism [MESH] |Epigenesis, Genetic [MESH] |HMGN Proteins/deficiency/genetics/*metabolism [MESH] |HMGN1 Protein/metabolism [MESH] |HMGN2 Protein/metabolism [MESH] |Lymphocyte Activation/*genetics [MESH] |Male [MESH] |Mice [MESH] |Nucleosomes/metabolism [MESH] |Promoter Regions, Genetic/genetics [MESH] |Protein Binding [MESH] |Regulatory Sequences, Nucleic Acid/*genetics [MESH]HMGN proteins modulate chromatin regulatory sites and gene expression (epmc).pdf DeepDyve Pubget Overpricing