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10.4103/2152-7806.189296

http://scihub22266oqcxt.onion/10.4103/2152-7806.189296
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C5009580!5009580!27625888
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suck abstract from ncbi


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pmid27625888      Surg+Neurol+Int 2016 ; 7 (ä): ä
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  • Traumatic brain injury and subsequent glioblastoma development: Review of the literature and case reports #MMPMID27625888
  • Tyagi V; Theobald J; Barger J; Bustoros M; Bayin NS; Modrek AS; Kader M; Anderer EG; Donahue B; Fatterpekar G; Placantonakis DG
  • Surg Neurol Int 2016[]; 7 (ä): ä PMID27625888show ga
  • Background:: Previous reports have proposed an association between traumatic brain injury (TBI) and subsequent glioblastoma (GBM) formation. Methods:: We used literature searches and radiographic evidence from two patients to assess the possibility of a link between TBI and GBM. Results:: Epidemiological studies are equivocal on a possible link between brain trauma and increased risk of malignant glioma formation. We present two case reports of patients with GBM arising at the site of prior brain injury. Conclusion:: The hypothesis that TBI may predispose to gliomagenesis is disputed by several large-scale epidemiological studies, but supported by some. Radiographic evidence from two cases presented here suggest that GBM formed at the site of brain injury. We propose a putative pathogenesis model that connects post-traumatic inflammation, stem and progenitor cell transformation, and gliomagenesis.
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