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2016 ; 15
(1
): 447
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Eave tubes for malaria control in Africa: initial development and semi-field
evaluations in Tanzania
#MMPMID27586055
Sternberg ED
; Ng'habi KR
; Lyimo IN
; Kessy ST
; Farenhorst M
; Thomas MB
; Knols BG
; Mnyone LL
Malar J
2016[Sep]; 15
(1
): 447
PMID27586055
show ga
BACKGROUND: Presented here are a series of preliminary experiments evaluating
"eave tubes"-a technology that combines house screening with a novel method of
delivering insecticides for control of malaria mosquitoes. METHODS: Eave tubes
were first evaluated with overnight release and recapture of mosquitoes in a
screened compartment containing a hut and human sleeper. Recapture numbers were
used as a proxy for overnight survival. These trials tested physical
characteristics of the eave tubes (height, diameter, angle), and different active
ingredients (bendiocarb, LLIN material, fungus). Eave tubes in a hut with closed
eaves were also compared to an LLIN protecting a sleeper in a hut with open
eaves. Eave tubes were then evaluated in a larger compartment containing a
self-replicating mosquito population, vegetation, and multiple houses and cattle
sheds. In this "model village", LLINs were introduced first, followed by eave
tubes and associated house modifications. RESULTS: Initial testing suggested that
tubes placed horizontally and at eave height had the biggest impact on mosquito
recapture relative to respective controls. Comparison of active ingredients
suggested roughly equivalent effects from bendiocarb, LLIN material, and fungal
spores (although speed of kill was slower for fungus). The impact of treated
netting on recapture rates ranged from 50 to 70 % reduction relative to controls.
In subsequent experiments comparing bendiocarb-treated netting in eave tubes
against a standard LLIN, the effect size was smaller but the eave tubes with
closed eaves performed at least as well as the LLIN with open eaves. In the model
village, introducing LLINs led to an approximate 60 % reduction in larval
densities and 85 % reduction in indoor catches of host-seeking mosquitoes
relative to pre-intervention values. Installing eave tubes and screening further
reduced larval density (93 % relative to pre intervention values) and virtually
eliminated indoor host-seeking mosquitoes. When the eave tubes and screening were
removed, larval and adult catches recovered to pre-eave tube levels. CONCLUSIONS:
These trials suggest that the "eave tube" package can impact overnight survival
of host-seeking mosquitoes and can suppress mosquito populations, even in a
complex environment. Further testing is now required to evaluate the robustness
of these findings and demonstrate impact under field conditions.
|Animals
[MESH]
|Disease Transmission, Infectious/*prevention & control
[MESH]